CHANGES IN THE HOMEOSTASIS LINKS IN CHILDREN WITH ACUTE RESPIRATORY PATHOLOGY OF THE UPPER RESPIRATORY TRACT UNDER THE INFLUENCE OF TREATMENT
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i2.14718Keywords:
Acute Respiratory diseases of the upper Respiratory tract (Acute Pharyngitis, Acute Bronchitis, Acute Tonsillitis), markers of inflammation, indicators of antioxidant protection, metabolic adaptation, correction, childrenAbstract
SUMMARY. Respiratory virus infection, which is associated with cytokine production, inflammation, cell death and other pathological processes, can be triggered by oxidative stress. Changes in the content of certain vitamins and trace elements, which creates conditions for the development of a number of pathological conditions, including acute and recurrent respiratory diseases.
The aim – to investigate the respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the child's body, oxidative stress, metabolic adaptation in them, the possibilities of correction.
Material and Methods. The investigated group included school-age children (10-14 years old). The general group of inflammatory diseases of the Respiratory tract (J000-J06) was considered. School children with a diagnosis of Acute Respiratory disease (ARI) of viral and bacterial origin which included local inflammatory lesions of the upper respiratory tract with presentation of Acute Pharyngitis (68.0 %), Acute Bronchitis (22.0 %), Acute Tonsillitis (10.0 %) were considered. A control group of school-age children (n=25), identical in age and sex, was included as well.
Results. Dynamic observation of children groups who received optimized (group 1, n=60) and basic (group 2, n=51) treatment was carried out, according to the protocols of the Ministry of Health and guidelines. Dynamic changes in indicators under the influence of various treatment methods were observed. It is especially worth noting the predominance of positive probable differences in the children group with an optimized therapy scheme in the levels of Total Bilirubin (р5=0.002), Total Protein (р5<0.01), ALT (р5<0.01), Urea (р5=0.03 ). There are also positive effects of optimized therapy on the state of the levels of trace elements Copper (р5<0.01), Zinc (р5<0.01), Iron (р5=0.04) and macroelement Calcium (р5<0.01). Positive correlations of Urea with IL-2 (r=0.30, p=0.02) and IL-4 (r=0.26, p=0.05) levels were revealed. The level of the Erythrocyte pool was correlated with IL-1 (r=-0.29, p=0.03), IL-4 (r=0.32, p=0.01), and TNF-α (r=-0.35, p=0.006). Creatinine value correlated with IL-10 (r=0.3, p=0.005), γ-IFN (r=0.42, p=0.001), TNF-α (r=0.25, p=0.05). Correlations of Ferritin presented positive correlation values with the level of Total Protein (r=0.26, p=0.04) and TNF-α (r=0.41, p=0.001).
Conclusions. After the appointment of the optimized treatment, there was a significant decrease in the reliable levels of CRP and γ-IFN by 7 and 4.4 times (by groups) and 5.8 and 3.2 times (by groups), respectively. Correlation relationships of urea levels with IL-2 (r=0.30, p=0.02) and IL-4 (r=0.26, p=0.05) were significant. The level of the erythrocyte pool was correlated with IL-1 (r=-0.29, p=0.03), IL-4 (r=0.32, p=0.01), TNF-α (r=-0.35 , p=0.006). Creatinine value correlated with IL-10 (r=0.3, p=0.005), γ-IFN (r=0.42, p=0.001), TNF-α (r=0.25, p=0.05). Correlations of ferritin presented positive correlation values with the level of total protein (r=0.26, p=0.04) and TNF-α (r=0.41, p=0.001).
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