CLINICAL-INSTRUMENTAL AND LABORATORY PARAMETERS ANALYSIS OF THE PATIENTS WITH ARTERIAL HYPERTENSION IN COMORBIDITY WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i2.14714Keywords:
arterial hypertension, chronic pancreatitis, lipidogram, echocardiographyAbstract
SUMMARY. The high medico-social significance of arterial hypertension (AH), as well as its complications and frequent comorbid conditions, which include damage to the gastrointestinal tract (GI) and pancreas (P) in the form of chronic pancreatitis (CP), determines the relevance of further scientific research on this problem.
The aim – to evaluate risk factors, indicators of daily monitoring and profile of blood pressure, intracardiac hemodynamics (according to echocardiography), thickness of the intima-media complex (according to sonography of carotid arteries) and lipid profile of patients with hypertension in combination with chronic pancreatitis.
Material and methods. An analysis of the medical records of 65 patients with 2 to 3 degree of hypertension, II stage of hypertension with concomitant CP, as well as 25 patients with hypertension without CP was carried out. The structural and functional features of the left ventricle and the mass of the myocardium of the left ventricle were determined using a two-dimensional echocardiographic Doppler examination on the BIOMEDICA device (USA) according to the standard method using a 3.5 MHz sensor.
Results. The number of patients with concomitant tobacco smoking was more significant by 18.2 % in case of arterial hypertension in comorbidity with CP compared to arterial hypertension alone, with the impact of a stress factor – by 13.8 %, with frequent alcohol consumption – by 21.8 %, and with rhythm disorders – by 11.1 % (p<0.05).
It was established that the presence of chronic pancreatitis in patients with arterial hypertension complicated the clinical course of the disease (higher average daily SBP by 4.17 %, DBP by 2.97 % and heart rate by 11.54 %, p<0.05).
Conclusions. The comorbidity of hypertension and CP was accompanied by a more significant disturbance of intracardiac hemodynamics (according to an increase in echocardiographic parameters of end-diastolic and end-systolic volumes, end-diastolic and end-systolic sizes by 8.25 %, 5.58 %, 4.54 %, and 6.80 %, respectively, thickening of the back wall of the left ventricle by 16.18 % and the interventricular membrane by 9.76 % compared to those in isolated arterial hypertension (p<0.05)), progression of atherosclerosis (according to the violation of the lipidogram (increase in the level cholesterol by 11.32 % and triglycerides by 29.17 %, a decrease in high-density lipoproteins by 21.43 %) and an increase in the thickness of the intima-media complex during sonographic examination of the carotid arteries by 29.09 % ((p<0.001).
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