THE RISK OF DEVELOPMENT OF DIABETIC NEPHROPATHY IN PATIENTS WITH DIFFERENT DURATION OF TYPE 2 DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i1.14537Keywords:
diabetic nephropathy, type 2 diabetes, glucoseAbstract
SUMMARY. The article presents changes in kidney function indicators depending on the duration of diabetes mellitus.
Diabetes mellitus (DM) is a global health problem, as it contributes to the high risk of developing many pathological processes, including the development of cardiovascular diseases, kidney damage, etc. Diabetic nephropathy today is one of the main problems as it is the cause of mortality and disability of patients. Diabetic damage to the kidneys, in particular the glomeruli and tubules, as well as the vessels that feed them can lead to the final (terminal) stage of kidney failure.
The aim – to investigate the level of urea nitrogen and the rate of glomerular filtration in the blood of patients with type 2 diabetes with different durations of the course of type 2 diabetes mellitus.
Material and Methods. 40 patients with type 2 diabetes mellitus were examined, including 20 patients with verified type 2 diabetes mellitus for up to 5 years (Group 1) and 20 patients with verified type 2 diabetes mellitus for more than 15 years (Group 2). The average age of patients is 65±5 years. The control group is 20 practically healthy persons of appropriate age.
Results. Studies have shown that kidney dysfunction is accompanied by a high level of urea nitrogen and a decrease in GFR, which disrupts the excretion of metabolic products and contributes to even greater intoxication of the human body.
Conclusions. The obtained data indicate that the damage to renal structures depends on the duration of the course of diabetes, in particular, the increase in the renal threshold of glucose level.
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