METABOLIC SYNDROME: INSIGHT INTO THE PROBLEM
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i1.14523Keywords:
arterial hypertension, dyslipidemia, ezetimibe, insulin resistance, metformin, obesityAbstract
SUMMARY. The study represents review of modern scientific knowledge on prevalence of the metabolic syndrome worldwide, its role in the pathogenesis of cardiovascular pathology, type 2 diabetes mellitus and possibilities of behavioral and pharmacological modification of its separate components.
The aim – to analyze the evidence of metabolic syndrome formation and development, means of its modification.
Material and Methods. Systematic review and bibliometric analysis of the data, obtained from the available scientific publications, was carried out.
Results. Over the past decades there has been a steady increase in the prevalence of obesity, type 2 diabetes, cardiovascular disease. Metabolic disorders, that occur due to hypodynamia, high-calorie diet, chronic stress, are diagnosed in approximately one third of the world’s population and considered the epidemic of the 21st century. Around 85 % of patients with type 2 diabetes have metabolic syndrome and, thus, higher risks of cardiovascular disease. Modification of different signs of metabolic syndrome has a positive effect on cardiovascular morbidity and mortality, increasing the duration and quality of life of such patients.
Conclusions. Despite the substantial literature data and considerable results of clinical studies of metabolic syndrome, mortality rates from cardiovascular complications among such patients remain high. This indicates the need for further study of this problem, search for opportunities for its early detection and prevention, effective treatment.
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