AGE CHANGES OF MASOMETRICAL PARAMETERS OF HEART PARTS IN EXPERIMENTAL ANIMALS
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i1.14401Keywords:
parts of the heart, age changes, massometryAbstract
SUMMARY. Cardiovascular pathology is an important medical and social problem today. Despite the progress in the diagnosis and correction of heart lesions, the structure and function of which continue to be studied by morphologists and clinicians.
The aim – to study the age-related patterns of changes in massometric parameters of heart parts in laboratory sexually mature white male rats.
Material and Methods. Separate weighing of heart parts of 32 laboratory sexually mature white male rats, which were divided into two groups, was carried out. The first group consisted of 15 specified six-month-old experimental animals, the second – 17 24-month-old male laboratory rats. Animals were euthanized by bloodletting under thiopental anesthesia. The heart was cut into six parts: left, right ventricles, left, right atrium, interventricular and interatrial septa. We carried out separate weighing of specified parts of heart muscle, determining the weight of heart, the weight of left and right ventricles, the left and right atrium, the interventricular septum, the interatrial septum, the indices of ventricles, Fulton, atria, the percents of ventricular masses, atria and septa, the index of the heart. Quantitative indicators were processed statistically.
Results. Uneven, disproportionate hypertrophy of parts of the heart occurs with age. The weight of heart increased by 33.5 %, left ventricle – by 36.6 %, right – by 27.6 %, left atrium – by 34.2 %, right – by 31.1 % (p<0.001). The ratio between the masses of parts of heart muscle, which adequately reflected the index of the ventricles, atria, and Fulton, changed significantly. The latter and the atrial index increased by 7.1 % and 2.3 %, respectively, the ventricular index decreased by 5.5 % (p<0.001).
Conclusions. The conducted studies established that with age in laboratory sexually mature white male rats, an uneven disproportional hypertrophy of heart parts occurs, which is characterized by an increase in their mass with a pronounced dominant increase in mass of left ventricle and left atrium, a significant violation of ratio between masses of the left and right ventricles, left and right atrium.
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