ACTIVITY OF SYSTEMIC INFLAMMATION AND THE LEVEL OF LEPTIN IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIFFERENT BODY WEIGHTS
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i1.14394Keywords:
myocardial infarction, C-reactive protein, leptyn, overweight, obesityAbstract
SUMMARY. In obese people the hormone leptin is determined in the blood in an excessive amount. It is known that it contributes to the development of endothelial dysfunction. Leptin causes a decrease in the synthesis of NO and an increase in the amount of monocyte chemotactic protein-1, which leads to vasoconstriction, as well as adhesion of leukocytes to the vascular wall.
The aim – to investigate systemic inflammatory activity and leptin levels in overweight and obese patients with ST-segment elevation myocardial infarction (STEMI).
Material and Methods. 44 patients were examined, in whom the concentration of leptin (enzyme-linked immunosorbent assay kit using the DBC analyzer and test system) and C-reactive protein (CRP) (hs CRP AccuBind® ELISA test system) in the serum was determined upon admission to the hospital and on the 30th day of the disease. Patients were divided into 3 groups depending on body mass index (BMI).
Results. At admission to the hospital, the plazma levels of leptin in STEMI patients in the presence of normal body weight were 6.65±0.55 ng/ml, in STEMI subjects in the presence of overweight – 16.01±1.73 ng/ml, and in STEMI patients with obesity I-III degree – 38.64±3.1 ng/ml. In patients with overweight and obesity, the values of this indicator were significantly higher than the leptin level in normal weight subjects. CRP levels were significantly higher in patients with complications compared with subjects without complications, both during hospitalization (15.12±1.12 mg/L vs. 5.17± 0.45 mg/L, p<0.001) and on the 30th day of observation (5.63±0.71 mg/l vs. 2.6±0.36 mg/l, p<0.001).
Conclusion. An increase of the body weight of patients is associated with significantly higher leptin levels, and among obese subjects the leptin resistance index (L/TG) is significantly higher than in normal body weight and overweight patients.
SRP levels were significantly higher in patients with complications compared to patients without complications. At the same time, a trend towards higher leptin levels was noted in patients with complications.
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