EFFECT OF SMOKING ON INDICATORS OF LIPID METABOLISM IN PATIENTS WITH ACUTE CORONARY SYNDROME AND CHRONIC KIDNEY DISEASE, AND THEIR ASSOCIATION WITH THE GLOMERULAR FILTRATION RATE
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i1.14366Keywords:
acute coronary syndrome, chronic kidney disease, smoking, glomerular filtration rate, lipid profileAbstract
SUMMARY. The paper presents the results of a study of characteristics of lipid metabolism disorders in patients with Acute Coronary Syndrome (ACS) and Chronic Kidney Disease (CKD), glomerular filtration rate- and smoking-dependent.
The aim – to study the characteristics of lipid metabolism disorders in patients with ACS and CKD, glomerular filtration rate- and smoking-dependent.
Material and Methods. 186 patients with ACS and CKD were examined; mean age: 60.34±0.88 years old. The patients were divided into two groups depending on their GFR: Group I – 73 patients with GFR <60 ml/min/1.73m2; Group II – 113 patients with GFR ≥60 ml/min/1.73m2. The patients of both groups were divided into two subgroups based on their smoking status: I s and II s – smokers, and I ns and II ns – non-smokers
Results. Mean total cholesterol (TC) (by 7.71 % (s) versus (ns), p<0.05), low-density lipoprotein cholesterol (LDL-C) (by 11.92 % (s) versus (ns), p<0.05), and non-high-density lipoprotein cholesterol (non-HDL-C) (by 9.52 % (s) versus (ns), p<0.05) levels were significantly higher in the group of smokers compared to non-smokers. Mean high-density lipoprotein cholesterol (HDL-C) levels were significantly lower and mean triglyceride (TG) levels were significantly higher in Group I patients compared to Group II patients: HDL-C – by 7.69 %, p<0.05; TG – by 14.97 %, p<0.05). The results of the study showed, regardless of the GFR, significant disorders in lipid metabolism in the subgroups of smokers (I s, II s) versus non-smokers (I ns, II ns), namely: significantly higher mean TC (by 14.71 % (I s) versus (I ns), p<0.05; by 8.51 % (II s) vs (II ns), p<0.05), LDL-C (by 19.54 % (I s) vs (I ns), p<0.05; by 12.38 % (II s) vs (II ns), p<0.05); TG (by 20.83 % (I s) vs (I ns), p<0.05; by 15.12 % (II s) vs (II ns), p<0.05), and non-HDL-C (by 16.82 % (I s) versus (I ns), p<0.05; by 11.67 % (II s) versus (II ns), p<0.05) levels and lower HDL-C (by 12.07 % (I s) versus (I ns), p<0.05); by 12.39 % (II s) versus (II ns), p<0.05) levels.
Conclusions. Mean pro-atherogenic lipid (TC, LDL-C, and non-HDL-C) fraction levels were significantly higher in the group of smokers compared to non-smokers. In patients with GFR <60 ml/min/1.73m2 (I), a significantly lower mean HDL-C level and higher TG level were recorded compared to the group of patients with GFR ≥60 ml/min/1.73m2 (II). Regardless of the GFR, significant pro-atherogenic disorders in lipid metabolism are observed in the subgroups of smokers (I s and II s) versus non-smokers (I ns and II ns), in particular, an increase in the TC, LDL-C, TG, and non-HDL-C levels and a decrease in HDL-C levels.
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