FEATURES OF TORCH INFECTION IN PARTURIENT MOTHERS WITH ALCOHOLIC LIVER DISEASE: THE THREAT OF INTRAUTERINE INFECTION OF THE FOETUS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i4.14308Keywords:
alcoholic liver disease, TORCH infection, women in labour, intrauterine fetal infectionAbstract
SUMMARY. The combination of several negative factors, such as alcohol abuse in combination with TORCH infection in women in labour, is unfavourable in terms of prognosis for pregnancy and fetal development.
The aim – to determine the features of TORCH infection and its impact on intrauterine infection of the fetus in women in labour with alcoholic liver disease (ALD).
Material and Methods. We examined 38 women in labour with ALD. The patients were divided into 2 groups: group I included 18 women in labour with ALD who were not diagnosed with TORCH infection, and group II consisted of women in labour with ALD who had antibodies to TORCH infections (n=20).
Results. All parturients with ALD of both groups were diagnosed with signs of asthenovegetative and dyspeptic syndromes. In group II women in labour, there was a pronounced, statistically significant increase in cytolytic and cholestatic syndrome compared to group I patients (women in labour with ALD who did not carry TORCH infection). Women in labour in both groups were more likely to have preterm delivery. At the same time, women in group I gave birth at 36.8±4.2 weeks of gestation, and in group II – at 33.2±5.0 weeks of gestation. In infants born to mothers with ALD during TORCH infection, signs of respiratory disorders, respiratory distress syndrome (RDS), hypoxic-ischemic damage (HID) of the central nervous system (CNS), congenital pneumonia, necrotizing enterocolitis, and intraventricular haemorrhage (IVH) of the brain of 1–4 degrees were observed.
Conclusions. ALD in women in labour increases the risk of intrauterine infection of the fetus with TORCH infection and is also a risk for preterm birth. TORCH infection in women in labour with ALD increases the risk of pathological disorders at birth, namely respiratory disorders, RDS, CNS and cerebral vascular disease.
References
Sira, M.M., Sira, A.M., Elhenawy, I.A., & Khalil, F.O. (2016). Prevalence of Serological Markers of TORCH Infections in Biliary Atresia and Other Neonatal Cholestatic Disorders. Peertechz. J. Pediatr. Ther., 2 (1), 13-17. DOI: https://doi.org/10.17352/2640-7612.000010
Abrahamovych, U.О., Abrahamovych, M.О., & Drobinska, N.V. (2013). TORCH-Infection and Its Possible Role in Syntropic Liver Damage in Patients with Systemic Lupus Erythematosus (literature review and clinical case description). Lviv Clinical Bulletin., 4(4), 43-51. DOI: https://doi.org/10.25040/lkv2013.04.043
Sadrin, O.G., Chernega, N.F., & Platonova, O.M. (2016). Osoblyvosti etiolohiyi ta perebihu zakhvoryuvan pechinky u ditey rannoho viku [Features of the etiology and course of liver diseases in young children]. Dytyachiy likar – Children's doctor, 3(48), 5-8 [in Ukrainian].
Lee, M.Y., Kim, M.H., Lee, W.I., Kang, S.Y., & Jeon, Y.L. (2016). Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Yonsei Med. J., 57(5), 1271-1275. DOI: 10.3349/ymj.2016.57.5.1271. DOI: https://doi.org/10.3349/ymj.2016.57.5.1271
Shet, A. (2011). Congenital and perinatal infections: throwing new light with an old TORCH. Indian J. Pediatr., 78(1), 88-95. DOI: 10.1007/s12098-010-0254-3. DOI: https://doi.org/10.1007/s12098-010-0254-3
Ville, Y., & Leruez-Ville, M. (2014). Managing infections in pregnancy. Curr. Opin. Infect. Dis., 27(3), 2517. DOI: 10.1097/QCO.0000000000000066. DOI: https://doi.org/10.1097/QCO.0000000000000066
Williams, E.J., Embleton, N.D., Clark J.E., Bythell, M., Ward Platt, M.P., & Berrington, J.E. (2013). Viral infections: contributions to late fetal death, stillbirth, and infant death. J. Pediatr., 163(2), 424-428. DOI: 10.1016/j.jpeds.2013.02.004. DOI: https://doi.org/10.1016/j.jpeds.2013.02.004
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S.E., & Horne, A.W. (2016). The role of infection in miscarriage. Hum. Reprod Update, 22(1), 116-133. DOI: 10.1093/humupd/dmv041. DOI: https://doi.org/10.1093/humupd/dmv041
Adams Waldorf, K.M., & McAdams, R.M. (2013). Inluence of infection during pregnancy on fetal development. Reproduction, 146(5), R151-162. DOI: 10.1530/REP-13-0232. DOI: https://doi.org/10.1530/REP-13-0232
