INDICATORS OF CYTOKINE STATUS (IL-6 AND IL-10) BY PATIENTS THAT HAVE UNDERGONE SURGERY UNDER GENERAL ANESTHESIA CONDITIONS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i3.14085Keywords:
postoperative cognitive dysfunctions, IL-6, IL-10, MoCA-testAbstract
SUMMARY. The aim – to set diagnostic value in determining the content of IL-6 and IL-10 for prediction of postoperative cognitive dysfunction.
Material and Methods. By 32 patients who underwent surgeries there was researched content of IL-6 and IL-10 in serum at pre- and postoperative period. The average age of the patients – 52.28±2.13 years old. Average duration of surgery – 78,91±5,04 minutes. Duration of anesthesia was average – 103.91±6.59 minutes. Division by the type of surgery, endoprosthesis – 17 patients (53.13 %), metal osteosynthesis – 15 patients (46.87 %). In order to assess the status of cognitive functions there was used Montreal scale assessment of cognitive functions (MoCA) to determine the level of anxiety and depression – Hospital Anxiety and Depression Scale (HADS). The control group was 22 practically healthy persons, representative by age and gender.
Results. Prior to surgery by the patients of the main group compared with the control one, only the level of IL-6 was significantly higher, which can be regarded as a reaction to trauma. Surgical intervention contributed to the growth of anti-inflammatory cytokine IL-6 in 3.57 times against moderate increase in anti-inflammatory – IL-10 (in 1.2 times).
Postoperative content of IL-6 was significantly higher in the group with endoprosthesis (p=0.04). It was found a correlation between the level of IL-6 and duration of surgery (r=0.77, p=0.001) levels of IL-10 and depression (r=0.64, p=0.013).
Conclusions. Surgery boosted levels of anti-inflammatory cytokines IL-6 on the background of moderate growth of anti-inflammatory – IL-10. Significantly higher levels of postoperative IL-6 was by the patients with anesthesia lasting more than 120 minutes, negatively correlating with a MoCA test result (r=-0.57, p=0.035). There were determined the peculiarities of cytokine system response status, depending on the nature of the pathology, on which orthopedic surgery is fulfilled.
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