QUANTITATIVE MORPHOLOGICAL STUDY OF THE CHARACTERISTICS OF VENOUS DRAINAGE DISORDERS FROM THE TESTIS IN CONDITIONS AT ETHANOL INTOXICATION
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i3.14083Keywords:
testicles, veins, morphometry, ethanolAbstract
SUMMARY. Alcoholism is a widespread medical and social pathology, which affects almost all organs and systems of the body. Features of violations of venous drainage from the testicles in conditions of ethanol intoxication have not been studied to the end.
The aim – is to investigate the peculiarities of venous drainage from the testicles in conditions of ethanol intoxication by quantitative morphological methods.
Material and Methods. The venous bed of the testicles of 62 laboratory sexually mature white male rats, which were divided into 2 groups, was morphologically investigated. The first group included 30 intact control animals, 2 – 32 rats, which were injected intragastrically with a 30 % ethanol solution at a dose of 2 ml per 100 g of body weight for 28 days once a day. Animals were euthanized by bloodletting under thiopental anesthesia 30 days after the beginning of the experiment. The diameters of postcapillary venules, venules, venous vessels, their lumen, wall thickness, the height of endotheliocytes, the diameter of their nuclei, the nuclear-cytoplasmic ratio in endotheliocytes and the relative volume of their lesions were determined on the histological preparations of testicles. Quantitative indicators were processed statistically.
Results. Pronounced structural rearrangement of the venous bed of testicles in conditions of long-term ethanol poisoning was established. Pronounced expansion of post-capillary venules and testicular venules, increase of outer and inner diameters of venous vessels, thinning of their walls, increase of relative volume of damaged endotheliocytes, disruption of nuclear-cytoplasmic relations in them were revealed. Venous hyperemia was complicated by hypoxia, dystrophy, necrobiosis of endotheliocytes, spermatogenic epitheliocytes, interstitial endocrinocytes, infiltration and sclerosis. Morphological changes predominated in the left testicle.
Conclusions. Long-term intoxication of body of laboratory sexually mature white male rats with ethanol leads to pronounced remodeling of the venous bed of the testicles, which is characterized by significant expansion and engorgement of venous vessels, violation of their venous drainage function, hypoxia, dystrophic, necrobiotic, infiltrative and sclerotic processes in the studied organs. The revealed structural rearrangement of venous vessels dominated in the left testicle.
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