FEATURES OF VAGINAL MICROBIOTA IN WOMEN OF REPRODUCTIVE AGE

Authors

  • N. Ya. Kravets I. Horbachevsky Ternopil National Medical University
  • P. H. Lykhatskyy I. Horbachevsky Ternopil National Medical University
  • L. M. Malanchuk I. Horbachevsky Ternopil National Medical University
  • I. Ya. Hospodarskyi I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/1811-2471.2023.v.i3.13899

Keywords:

bacterial vaginosis, dysbiosis, vaginal thrush, aerobic vaginitis, microorganisms, vaginal microbiota

Abstract

SUMMARY. Decreased lactobacilli count on the mucous membrane of the vagina and cervix leads to changes in the species composition of vaginal microbiota and is accompanied by inflammatory processes in the female genital organs.

The aim – to investigate the species spectrum of the vaginal microbiome in women of reproductive age without signs of infectious-inflammatory processes, as well as in the presence of inflammatory processes in comparison with normocenosis.

Material and Methods. We examined 75 female patients aged 20–45 with various disorders of vaginal microbiota. The examined patients were divided into three age groups: the first group (20 women) – 20–30 years old, the second group (30 women) – 30–40 years old, the third group (25 women) – 35–45 years old, and a control group (10 women) with a normal vaginal microbiota. The laboratory investigations included bacterioscopic, bacteriological, and cultural methods for studying the species composition (CFU/mL) and microbial associations in different nosological forms according to Kopeloff's modification.

Results. The most frequently identified microorganisms in the vaginal microbiota of the examined women: Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Prevotella spp., Streptococcus spp., Bacteroides spp., Enterococcus spp., Candida albicans, Fusobacterium spp., Peptostreptococcus spp., Eubacterium spp., and Veillonella spp., with varying amount CFU/mL.

Conclusions. Microbiological examination of the vaginal microbiota in women allowed for the detection of disturbances in the species composition of microorganisms and the establishment of their nosological form.

References

Polishchuk, I. (2020). Kliniko-laboratorna otsinka vplyvu seknidazolu ta klindamitsynu pry bakterialnomu vahinozi u zhinok reproduktyvnoho viku/ Ukrayina [Clinical and laboratory assessment of the effect of secnidazole and clindamycin in bacterial vaginosis in women of reproductive age]. Bukovynskyy medychnyy visnyk – Bukovyna Medical Herald, 24, 3, 73-79 [in Ukrainian]. DOI: https://doi.org/10.24061/2413-0737.XXIV.3.95.2020.75

Klymnyuk, S., Mykhaylyshyn, H., & Malanchuk, L. (2019). Mikrobiolohichni osoblyvosti bakterialnykh vahinoziv u zhinok riznykh vikovykh katehoriy ta shlyakhy yikh mikrobiolohichnoyi korektsiyi [Microbiological features of bacterial vaginosis in women of different age categories and ways of their microbiological correction]. Zdobutky klinichnoyi ta eksperymentalnoyi medytsyny – Achievements of Clinical and Experimental Medicine, 3, 21-31 [in Ukrainian].

Dovha, I., Chastiy, T., Ivannik, V., & Kazmirchuk, V. (2022). Vahinity ta problemy yikh likuvannya [Vaginitis and problems of their treatment]. Annals of Mechnikov institute, 2, 9-20 [in Ukrainian].

Mykhaylyshyn, H., I. Klymnyuk, S., & Spivak, M. (2020). Vidnovlennya mikrobiomu vahiny pry bakteriynomu vahinozi iz zastosuvannyam probiotyka Dialak [Restoration of the vaginal microbiome in bacterial vaginosis with the use of Dialak probiotic]. Infektsiyni khvoroby – Infectious Diseases, 4, 18-24 [in Ukrainian].

Ivanova, S., Konkov, D., & Yakovleva, O. (2022). Mikrobiotsenoz zhinky, yoho metabolichna aktyvnist ta adekvatna korektsiya [Microbiocenosis of a woman, its metabolic activity and adequate correction with probiotics]. Vinnytskyy natsionalnyy medychnyy universytet im. M. I. Pyrohova – Vinnytsia National Medical University named after M. I. Pyrohov [in Ukrainian].

Tatarchuk, T., Zakharenko, N., Manolyak, I., Solskyy, V. & Tutchenko, T. (2023). Problema retsydyvnoho bakterialnoho vahinozu: suchasni stratehiyi [The problem of recurrent bacterial vaginosis: modern strategies]. Reproduktyvna endokrynolohiya – Reproductive Endocrinology, 67, 56-62 [in Ukrainian]. DOI: https://doi.org/10.18370/2309-4117.2023.67.56-62

Podolskyy, V., Podolskyy, V., & Ponomariova, I. (2023). Probiotyky yak neobkhidna skladova kompleksnoyi terapiyi poshkodzhennya mikrobiotsenozu nyzhnoho rivnya orhaniv reproduktyvnoyi systemy u zhinok fertylnoho viku [Probiotics as a necessary component of complex therapy for disorders of the microbiocenosis of the lower level of the organs of the reproductive system in women of childbearing age]. Reproduktyvne zdorovya zhinky – Women's Reproductive Health., 2, 26-32 [in Ukrainian].

Zaporozhan, V., & Podolskyy, V. (2014). Reproduktyvne zdorov'ya zhinok pry zakhvoryuvannyakh zapalnykh zakhvoryuvan statevykh orhaniv [Reproductive health of women with chronic inflammatory diseases of the genital organs]. Chervona Ruta-Turs – Chervona Ruta Tours., 168-182 [in Ukrainian].

Pyrohova, V., Shurpyak, S., Okhabska, I., & Dyakunchak, Yu. (2022). Mikrobiota pikhvy ta yiyi zvyazok iz reproduktyvnym zdorovyam [Vaginal microbiota and its relation to reproductive health]. Reproduktyvne zdorovya – Reproductive Health, 4, 57-61 [in Ukrainian].

Pryymak, O., & Henyk, N. (2022). Kliniko-diahnostychni aspekty stanu ekosystemy slyzovoyi pry retsydyvnomu bakterialnomu vahinozi u zhinok reproduktyvnoho viku iz patolohiyeyu ekzo-endotserviksu [Clinical and diagnostic aspects of the state of the mucosal ecosystem in recurrent bacterial vaginosis in women of reproductive age with pathology of the exo-endocervix]. Aktualni pytannya pediatriyi, akusherstva ta hinekolohiyi – Actual Issues of Paediatrics, Obstetrics and Gynecology, 1, 5-10 [in Ukrainian].

Podolskyy, Vl., & Podolskyy, V. (2020). Osoblyvosti zminy vahinalnoyi mikrobioty u zhinok fertylnoho viku, yak mozhlyvyy mekhanizm rozvytku zapalnykh zakhvoryuvan statevykh orhaniv ta suchasni mozhlyvosti korektsiyi [Peculiarities of changes in the vaginal microbiota in women of childbearing age, as a possible mechanism of chronic inflammatory diseases of the genital organs and modern possibilities of correction]. Zdorove zhenshchyny – Women's Health, 2(148), 50-52 [in Ukrainian].

Martínez-García, E., Martínez-Martínez, J.C., Martín-Salvador, A., González-García, A., Pérez-Morente, M.Á., Álvarez-Serrano, M.A., & García-García, I. (2023). Epidemiological Profile of Patients with Vulvovaginal Candidiasis from a Sexually Transmitted Infection Clinic in Southern Spain. Pathogens, 12, 756. DOI: https://doi.org/10.3390/pathogens12060756

Published

2023-08-23

How to Cite

Kravets, N. Y., Lykhatskyy, P. H., Malanchuk, L. M., & Hospodarskyi, I. Y. (2023). FEATURES OF VAGINAL MICROBIOTA IN WOMEN OF REPRODUCTIVE AGE. Achievements of Clinical and Experimental Medicine, (3), 110–114. https://doi.org/10.11603/1811-2471.2023.v.i3.13899

Issue

Section

Оригінальні дослідження