RESEARCH OF THE COGNITIVE SPHERE IN PATIENTS WITH DIFFERENT TYPES OF ENCEPHALOPATHIES
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i2.13895Keywords:
cognitive impairment, post-traumatic encephalopathy, chronic alcohol-induced encephalopathy, post-infectious encephalopathy, chronic ischemia of the brain, MoCAAbstract
SUMMARY. Cognitive impairment, as a dominant factor in socio-psychological disability of patients, may depend on a combination of etiological, structural and morphological factors of encephalopathy, as well as numerous characteristics of the patient: age, sex, anthropometric indicators, duration of the disease, general clinical data, level of education and profession.
The aim – to study the features of cognitive disorders in the most common types of encephalopathies.
Material and Methods. A comprehensive examination of 520 patients was carried out, of which the number of patients with PTE was 145, with SVD – 145, with AE –102 and PIE –128. Gender, age, catamnesis, level of education, presence or absence of concomitant pathologies were taken into account. A clinical and neurological examination, the Montreal Cognitive Assessment, and statistical methods (Statistica 10.0) were used.
Results. The result of the MoCA test in the examined subjects was as follows: in patients with PTE – (23.99±2.40) points, in patients with SVD – (21.26±4.06) points, in AE – (21.74±4.24) points, with PIE – (23.48±3.33) points. Cognitive disorders at the level of mild degree were established in patients of all studied groups. At the same time, statistically significant differences were found between the groups of patients with PTE and SVD and AE; SVD and PIE; AE and PIE. Mild cognitive impairment was found in 68.28 % of patients with PTE, 72.41 % with SVD, 66.67 % of patients with AE, and 53.13 % of patients with PIE. Moderate deficiency was found in 3.45 % of patients with PTE, 8.28 % with SVD, 12.75 % with AE, and 6.25 % with PIE. Expressed cognitive impairment occurred only in 1.38 % with SVD and 0.98 % with AE. At the same time, statistically significant differences in cognitive impairment were found between patients with PTE compared to all other groups and patients with PIE compared to other groups of patients.
Conclusions. Cognitive impairments occurred in all types of encephalopathies: in 82.07 % of patients with SVD, 80.39 % – with AE, 71.72 % – with PTE, 59.37 % – with PIE, and were mainly manifested by mild cognitive deficits. At the same time, statistically significant differences were established between groups of patients with PTE and SVD and AE; SVD and PIE; AE and PIE. No reliable influence of gender, age, and catamnesis factor on the severity of cognitive manifestations was established. However, a probable influence of the catamnesis factor was established in patients with PTE (c2=13.44; p=0.037).
References
McKee, A.C., Stein, T.D., Huber, B.R., Crary, J.F., Bieniek, K., Dickson, D., ... Daneshvar, D.H. (2023). Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta Neuropathologica, 145(4), 371-394. DOI: https://doi.org/10.1007/s00401-023-02540-w
Muyitdinovna, X.S. (2022). The role of hyperhomocyteinemia in the development of cognitive disorders in chronic brain ischemia. Web of Scientist: International Scientific Research Journal, 3(8), 442-453.
Jahongirovich, M.J. (2022). Lesions of the Central Nervous System in Chronic Alcohol Intoxication. European Journal of Innovation in Nonformal Education, 2(12), 31-37.
Anand, S.K., Ahmad, M.H., Sahu, M.R., Subba, R., & Mondal, A.C. (2022). Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration. Cellular and Molecular Neurobiology, 1-20. DOI: https://doi.org/10.1007/s10571-022-01308-2
Davé, V.A., & Klein, R.S. (2023). The multitaskers of the brain: Glial responses to viral infections and associated post-infectious neurologic sequelae. Glia, 71(4), 803-818. DOI: https://doi.org/10.1002/glia.24294
Zhang, Q., Fan, W., Sun, J., Zhang, J., & Yin, Y. (2023). Review of Neurofilaments as Biomarkers in Sepsis-Associated Encephalopathy. Journal of Inflammation Research, 161-168. DOI: https://doi.org/10.2147/JIR.S391325
Atherton, K., Han, X., Chung, J., Cherry, J. D., Baucom, Z., Saltiel, N., ... Mez, J. (2022). Association of APOE genotypes and chronic traumatic encephalopathy. JAMA Neurology, 79(8), 787-796. DOI: https://doi.org/10.1001/jamaneurol.2022.1634
Stoian, A., Stoian, M., Bajko, Z., Maier, S., Andone, S., Cioflinc, R.A., ... & Balasa, R. (2022). Autoimmune encephalitis in COVID-19 infection: our experience and systematic review of the literature. Biomedicines, 10(4), 774. DOI: https://doi.org/10.3390/biomedicines10040774
Kudokotseva, O.V., Lomakin, I.I., & Babiichuk, V.H. (2022). Khronichna arterialna hipertenziia yak odna z prychyn rozvytku dystsyrkuliatornoi entsefalopatii [Chronic arterial hypertension as one of the causes of the development of dyscirculatory encephalopathy]. Multidisciplinary Academic Research, Innovation and Results, 13, 379 [in Ukrainian].
Babiichuk, V., Lomakin, I., Kudokotseva, O., Babiichuk, L., & Aidarova, V. (2021). Dystsyrkuliatorna entsefalopatiia. Suchasni aspekty etiopatohenezu [Dyscirculatory encephalopathy. Modern aspects of etiopathogenesis]. Scientific Collection “InterConf”, 51, 271-277 [in Ukrainian].
Ushakova, A. (2019). Zalezhnist vyrazhenosti kohnityvnykh porushen vid morfolohichnykh zmin holovnoho mozku za danymy mrt u khvorykh na dystsyrkuliatornu entsefalopatiiu II stadia – Dependence of severity of cognitive disorders on morphological changes of the brain according to MRI data in patients with dyscirculatory encephalopathy stage II. Proceedings of the XXIII International Med. congress of students and young scientists. Ternopil: TNMU «Ukrmedknyha» [in Ukrainian].
Salii, Z.V. (2020). Khronichna posttravmatychna entsefalopatiia. Pohliad na problemu [Chronic post-traumatic encephalopathy. A view of the problem]. Visnyk medychnykh i biolohichnykh doslidzhen – Bulletin of Medical and Biological Research, 3, 167-174 [in Ukrainian].
Sun, Y., Bai, L., Niu, X., Wang, Z., Yin, B., Bai, G., ... Zhang, M. (2019). Elevated serum levels of inflammation-related cytokines in mild traumatic brain injury are associated with cognitive performance. Frontiers in Neurology, 10, 1120. DOI: https://doi.org/10.3389/fneur.2019.01120
de Freitas Cardoso, M.G., Faleiro, R.M., De Paula, J.J., Kummer, A., Caramelli, P., Teixeira, A.L., ... Miranda, A.S. (2019). Cognitive impairment following acute mild traumatic brain injury. Frontiers in Neurology, 10, 198. DOI: https://doi.org/10.3389/fneur.2019.00198
Gorgoraptis, N., Zaw-Linn, J., Feeney, C., Tenorio-Jimenez, C., Niemi, M., Malik, A., ... Sharp, D.J. (2019). Cognitive impairment and health-related quality of life following traumatic brain injury. NeuroRehabilitation, 44(3), 321-331. DOI: https://doi.org/10.3233/NRE-182618
Schneider, A.L., Huie, J.R., Boscardin, W.J., Nelson, L., Barber, J.K., Yaffe, K., ... TRACK-TBI Investigators (2022). Cognitive outcome 1 year after mild traumatic brain injury: results from the TRACK-TBI study. Neurology, 98(12), e1248-e1261. DOI: https://doi.org/10.1212/WNL.0000000000200041
Lai, J.Q., Shi, Y.C., Lin, S., & Chen, X.R. (2022). Metabolic disorders on cognitive dysfunction after traumatic brain injury. Trends in Endocrinology & Metabolism. DOI: https://doi.org/10.1016/j.tem.2022.04.003
Xu, W., Yue, S., Wang, P., Wen, B., & Zhang, X. (2022). Systemic inflammation in traumatic brain injury predicts poor cognitive function. Immunity, Inflammation and Disease, 10(3), e577. DOI: https://doi.org/10.1002/iid3.577
