INFLUENCE OF VITAMIN D STATUS ON THE LEVEL OF LEPTIN AND ADIPONETIN IN CHILDREN WITH OVERWEIGHT AND OBESITY
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i1.13729Keywords:
25(OH)D, leptin, adiponectin, vitamin D, childrenAbstract
SUMMARY. It is known that adipose tissue is an active endocrine organ that produces a number of important adipocytokines, in particular, adiponectin, leptin, tumor necrosis factor and others. Adipokines regulate the homeostasis of fat mass, lipid and carbohydrate metabolism, the tone of blood vessels, as well as the sensitivity of cells to insulin. Experimental studies have shown the role of vitamin D in the regulation of leptin secretion and inhibition of adipogenesis.
The aim – to determine the relationship between leptin and adiponectin levels and 25(OH)D in overweight and obese adolescents.
Material and Methods. 136 overweight and obese adolescent children and 60 control group individuals with normal body weight were examined. All children underwent anthropometric measurements, biochemical studies of indicators of lipid and carbohydrate metabolism, determination of the level of 25(OH)D, leptin and adiponectin in the blood.
Results and Сonclusions. In adolescent children with excess body weight and obesity, an inverse correlation between the blood level of 25(OH)D and leptin (r=-0.498 (p<0.001)) and a direct correlation of 25(OH)D with adiponectin (r=0.592 (p<0.001)).
In the case of vitamin D deficiency in adolescents with excess body weight and obesity, direct reliable correlations of leptin with body weight, BMI, OT, OS, OT/OS, OT/height, and negative correlations of adiponectin with the same were established. anthropometric indicators.
The level of adipokines in the blood of adolescents with excess body weight and obesity and vitamin D deficiency has a reliable effect on the criteria of metabolic exchange.
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