MORPHOMETRIC ASPECTS OF REMODELING OF THE ARTERIAL BAD OF THE PROSTATE IN THE CONDITIONS AT CHRONIC ALCOHOL INTOXICATION
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i1.13728Keywords:
prostate, arteries, chronic alcohol intoxication, morphometryAbstract
SUMMARY. Chronic ethanol intoxication is accompanied by damage to almost all organs and systems of the body. The peculiarities of remodeling of arterial bed of the prostate at this pathology have not been sufficiently studied.
The aim – morphometrically investigate the structural changes of prostate arteries under conditions of chronic alcohol intoxication.
Material and Methods. The prostate of 62 laboratory sexually mature white male rats, which were divided into 2 groups, was studied. The first group (30 animals) served as a control. Rats of the second group (32 animals) were injected intragastrically with a 30 % ethanol solution at the rate of 2 ml per 100 g of body weight for 28 days once a day. Rats were euthanized by bloodletting under thiopental anesthesia 30 days after the start of the experiment. Medium- and small-caliber arteries were studied on micropreparations of prostate gland, where their outer and inner diameters, media thickness, adventitia, Vogenvoort and Kernogan indices, height of endotheliocytes, diameter of their nuclei, nuclear-cytoplasmic relations in these cells, relative volume of damaged endotheliocytes were determined. Quantitative values were processed statistically.
Results. Pronounced remodeling of arteries of prostate gland in conditions of chronic alcohol intoxication was established. Arterial wall thickening, media thickness growth, adventitia, narrowing of their lumen, changes in Vogenvoort and Kernogan indexes, damage to endotheliocytes, and disruption of nuclear-cytoplasmic relations in them were revealed. Structural changes dominated in the small-caliber arteries of the prostate.
Conclusions. The conducted studies and the obtained results indicate that chronic alcohol intoxication in laboratory sexually mature white male rats leads to pronounced remodeling of arterial bed of prostate, which is characterized by thickening of arterial wall, narrowing of their lumen, significant changes in the Wogenvoort and Kernogan indices, atrophic, dystrophic and necrobiotic changes endotheliocytes, disruption of their structural cellular homeostasis, endothelial dysfunction, hypoxia, dystrophic-necrotic changes in cells and stromal structures, infiltration and sclerosis. The degree of structural changes dominates in small-caliber arteries.
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