PECULIARITIES OF MORPHOMETRIC REARRANGEMENT OF THE BRAIN BLOOD VESSELS UNDER THE INFLUENCE OF EXPERIMENTAL STENOSIS OF THE ABDOMINAL AORTA CAUDAL PART IN RATS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i1.13721Keywords:
aorta, occlusion, full blood, ischemiaAbstract
SUMMARY. Disorders of cerebral blood circulation belong to fairly frequent diseases, and their clinical manifestations require long-term restorative treatment with an unpredictable effect. However, cardiovascular changes leading to the development of acute ischemic damage to the brain make up about half of all pathogenetic options for the course of cerebral blood flow disorders. At the same time, it is known that acute disorders of cerebral blood flow are also registered during surgical treatment of occlusive lesions of the aorto-femoral segment. Therefore, experimental establishment of the nature and dynamics of morphological changes in brain tissues in various disorders of central hemodynamics can help prevent negative consequences and improve the results of treatment of obliterating diseases of the main vessels.
The aim – to study the dynamics of cerebral blood vessel remodeling under the influence of experimental stenosis of the abdominal aorta caudal part in rats.
Material and Methods. The material for the study was 36 white sexually mature rats, of which 6 were the control group, the other 30 animals underwent narrowing of the abdominal aorta. For histological examination, pieces of tissue were taken from different parts of the brain and paraffin sections were made. A morphometric assessment of the branches of the cerebral arteries was carried out by determining the thickness of the muscle layer, the Vogenvoort index, and the arteriolo-venular index.
Results. According to the results of the research, it was established that dosed narrowing of the abdominal aorta leads to the emergence of a whole complex of morphological signs that indicate significant changes in intra-organ blood flow in the vessels of the brain under simulated experimental pathology.
Conclusions. Vasodilatation of medium-sized vessels with simultaneous vasoconstriction of small arteries was noted as the primary reaction of cerebral vessels with stenosis of the lower abdominal aorta in rats, which in the long term was replaced by partial recovery of the morphofunctional state of cerebral blood vessels.
References
Dybiak, Yu.M. (2014). Stan hemodynamiky pry riznykh morfolohichnykh variantakh urazhennia arterialnoho rusla patsiientiv iz khronichnoiu krytychnoiu ishemiieiu nyzhnikh kintsivok [The state of hemodynamics in different morphological variants of the lesion of the arterial bed in patients with chronic critical ischemia of the lower extremitie]. Krovoobih ta hemostaz – Blood Circulation and Hemostasis, 1-2, 73-77 [in Ukrainian].
Venher, I.K., Herasymiuk, N.I., Kostiv, S.Ya., Loiko, I.O., & Husak, M.O. (2019). Patohenetychne obhruntuvannia profilaktyky ta korektsii reperfuziino-reoksyhenatsiinoho syndromu pry revaskuliaryzatsii arterialnoho rusla v umovakh khronichnoi krytychnoi ishemii nyzhnikh kintsivok. [Pathogenetic justification of prevention and correction of reperfusion-reoxygenation syndrome during revascularization of the arterial bed in conditions of chronic critical ischemia of the lower extremities]. Visnyk naukovykh doslidzhen – Herald of Scientific Research, 2, 19-23 [in Ukrainian].
Kostiv, S.Ya., Kolotylo, O.B., & Venher, I.K. (2018). Patofiziolohichno obgruntovana profilaktyka ta likuvannia reperfuziino-reoksyhynatsiinoho syndromu pry revaskuliaryzatsii nyzhnikh kintsivok v umovakh khronichnoi krytychnoi ishemii nyzhnikh kintsivok [Pathophysiologically based prevention and treatment of reperfusion-reoxygenation syndrome during revascularization of the lower extremities in conditions of chronic critical ischemia of the lower extremities]. Naukovyi visnyk Uzhhorodskoho universytetu -– Scientific Bulletin of Uzhhorod University, 2(58), 24-28 [in Ukrainian].
Baines, C.P. (2011). How and when do myocytes die during ischemia and reperfusion: the late phase. J. Cardiovasc. Pharmacol., 16(3-4), 239-243. DOI: https://doi.org/10.1177/1074248411407769
Herasymiuk I. Ye., Pylypko I. V., & Ostrovska L. O. (2010). Patent na korysnu model 60262 Ukraina, MPK A 61 M 5/00, G 09 B 23/00. Prystrii dlia dozovanoho zvuzhennia sudyn zaiavnyk i vlasnyk patentu Ternopilskyi derzhavnyi medychnyi universytet imeni I. Ya. Horbachevskoho. – № 201015339 ; zaiavl. 20.12.2010 ; opubl. 10.06.2011, Biul. № 11. 5 – Utility model patent 60262 Ukraine, IPC A 61 M 5/00, G 09 B 23/00. The device for dosed vasoconstriction. The applicant and owner of the patent I. Horbachevsk. Ternopil State Medical University – No. u201015339; statement 20.12.2010; published 10.06.2011, Bull. No. 11 [in Ukrainian].
