PATHOGENETIC ASPECTS OF VITAMIN INSUFFICIENCY FORMATION IN CHRONIC PANCREATITIS

Abstract

SUMMARY.  In the development and progression of chronic pancreatitis, the role of violations in the vitamin status, the development of anemia syndrome, as well as the systemic inflammatory process have been proven.

The aim – to investigate the state of indicators of anemia syndrome and vitamin status and to study their mutual influence in patients with CP.

Material and Methods. 117 patients with CP were examined. It was done to all patients a general blood test, determined the level of serum iron, ferritin, transferrin, a transferrin saturation with iron, the level of vitamin C, vitamins B1 and B6, and 25-OHD.

Results. The levels of correlation between indicators of anemia syndrome and vitamin status, namely the level of ascorbic acid, thiamine, pyridoxine, 25-OH vitamin D, retinol, and tocopherol, are significant for most indicators and correspond to the level of the existing moderate correlation, and for some indicators and significant (the level of ascorbic acid and the total number of erythrocytes, the level of hemoglobin and serum iron, the level of retinol and the level of total protein).

Conclusions. The presence of anemia syndrome of various degrees was found in 81.2 % of the studied patients, which indicates the development of trophological disorders in patients with CP, which are often overlooked by doctors. It was also determined the presence of a statistically significant decrease in the level of all studied vitamins in patients with CP (p<0.05), which indicates the presence of trophological disorders of the hypovitaminosis type. The presence of correlations of moderate and significant strength between indicators of anemia syndrome and vitamin status (p<0.05) was established, which indicates the mutually aggravating influence of different types of trophological disorders in patients with CP.