CORRELATED INTERACTIONS OF DYSLIPID AND DISHORMONAL DISORDERS IN PATIENTS WITH HYPOTHYROIDISM

Abstract

SUMMARY. The problem of the development of atherosclerosis as one of the basic pathogenetic syndromes in any nosology, including with hypothyroidism (HT) is an extremely urgent problem, especially since the data of scientific sources testify to contradictory results regarding the parameters of the lipid profile in this category of patients.

The aim – to investigate the parameters of the lipid profile of patients with HT and their dependence on the levels of thyroid hormones.

Material and Methods. 44 ambulatory HT patients aged 26 to 69 were examined. All patients underwent a general clinical examination of the patient; determination of the thyroid profile (thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels). Violations of lipid status were assessed by the level of total cholesterol (CHL), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (LDL), high-density lipoprotein (HDL), and the atherogenic factor (AF).

Results. The assessment of the above indicators indicates the presence of pathological changes in lipid metabolism in 72.73 % of the group of patients with HT. HDL as an anti-atherogenic blood factor was significantly reduced in HT patients compared to the control group. It was found that the level of TG was significantly higher by 0.6 mmol/L (31.09 %), CKD was higher by 2.54 mmol/L (67.5 %), and the level of LDL prevailed by 1.68 mmol/L (75.67 %) in the group of patients with HT than in the control group (р<0.05); AF was three times higher in the group of HT patients compared to the control group (p<0.001). According to lipidogram data, hyperlipoproteinemia of type IIa (14 patients – 31.82 %) and IIb types (18 patients – 40.91 %) was found in patients on HT.

Conclusions. Based on the correlation-regression analysis, a reliable dependence of the levels of HC, TG, LDL, LDL, AF, HDL was established (respectively r=0.67, r=0.69, r=0.64, r=0.69, r =0.72, r=-0.52; (р<0.05)) from the levels of thyroid-stimulating hormone, as well as free thyroxine (respectively r=-0.55, r=-0.49, r=-0, 54, r=-0.49, r=-0.59, r=0.52; (р<0.05). The obtained results prove that a decrease in the content of thyroid hormones in blood serum during HT is a predictor of lipid metabolism disorders towards atherosclerosis .