CYTOKINE STATUS IN WOMEN OF REPRODUCTIVE AGE WITH AUTOIMMUNE THYROIDITIS
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i4.13508Keywords:
autoimmune thyroiditis, cytokine status, womenAbstract
SUMMARY. In recent years, in Ukraine and other countries of the world, an increase in the frequency of thyroid diseases of autoimmune origin has been observed. Pathophysiological understanding of the features of autoimmune disorders in autoimmune thyroiditis will make it possible to justify the need to prescribe certain drugs.
The aim – to determine the level of TNFα, IL-6, IL-10, IL-17, IL-23 in patients with autoimmune thyroiditis, as well as to establish the relationship between the level of interleukins and the function of the thyroid gland in autoimmune thyroiditis.
Material and Methods. We examined 98 patients aged 18–43 with autoimmune thyroiditis and 30 women of the control group. The functional state of the thyroid gland was studied by determining the levels of thyroid-stimulating hormone, free thyroxine, and free triiodothyronine in blood serum, and the level of thyroperoxidase and thyroglobulin antibodies were determined. The state of the systemic and local inflammatory process was assessed by the parameters of TNFα, IL-6, and IL-10, IL-17, and IL-23.
Results and Conclusions. In all patients with autoimmune thyroiditis, changes in cytokine status were detected, while there were some differences in cytokine status depending on the clinical variant of autoimmune thyroid disease. A positive correlation was found between the level of TNF-α and the level of ATPO (r=0.62, p<0.05), between the level of IL-6 and the level of ATPO (r=0.44, p<0.05), between the level of IL-10 and ATPO (r=0.36, p<0.05), the level of IL-17 and the level of ATPO (r=0.42, p<0.05), the level of IL-23 and the level of ATPO (r=0.42, p<0.05). A positive correlation between the level of TNF-α and the level of TSH (r=0.58, p<0.05), between the level of IL-6 and the level of TSH (r=0.41, p<0.05) was studied. the level of IL-10 and ATPO (r=0.32, p<0.05), the level of IL-17 and the level of TSH (r=0.37, p<0.05), the level of IL-23 and the level of TSH (r=0.39, p<0.05).
References
Tkachenko, V.I., Maksymets, Ya.A., Vydyborets, N.V., & Kovalenko, O.F. (2018). Analiz poshyrenosti tyreoidnoi patolohii ta zakhvoriuvanosti na nei sered naselennia Kyivskoi oblasti ta Ukrainy za 2007–2017 rr. [Analysis of the prevalence of thyroid pathology and its incidence among the population of Kyiv region and Ukraine for 2007–2017]. Mizhnarodnyi endokrynolohichnyi zhurnal – International Journal of Endocrinology, 14(3), 279-284. DOI: 10.22141/2224-0721.14.3.2018.136426 [in Ukrainian].
Pankiv, V.I., Yuzvenko, T.Iu., Korytko, O.O., & Sadoviak, I.D. (2014). Shliakhy udoskonalennia nadannia medychnoi dopomohy khvorym na tyreopatii iz suputnoiu patolohiieiu [The way to improve the provision of medical care to patients with thyropathies with accompanying pathology]. Mizhnarodnyi endokrynolohichnyi zhurnal – International Journal of Endocrinology, 7(63), 106-109 [in Ukrainian].
Vlasenko, M.V. (2009). Autoymmunnyi tyreoydyt u podrostkov [Autoimmune thyroiditis in adolescents]. V:100 yzbrannykh lektsyi po эndokrynolohyy pod red. Yu.Y. Karachentseva, A.V. Kazakova, N.A. Kravchun, Y.M. Ylynoi. Kharkiv – In: 100 selected lectures on endocrinology, ed. Yu. I. Karachentseva, A. V. Kazakova, N. A. Kravchun, I. M. Ilyina. Kharkiv, 372-378 [in Russian].
Brix, T., & Hegedus, L. (2012). Twin studies as a model for exploring the etiology of autoimmune thyroid disease. Clin. Endocrinol., 76, 457-464.
Effraimidis, G., Strieder, T.G., Tijssen, J.G., & Wiersinga, W.M. (2011). Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study. Eur. J. Endocrinol, 164, 107-113.
Fatemeh Esfahanian, Roghayeh Ghelich, Hoda Rashidian, Zohreh Jadali (2017). .Increased Levels of Serum Interleukin-17 in Patients with Hashimoto's Thyroiditis. Indian J. Endocrinol. Metab., 21(4), 551-554. DOI: 10.4103/ijem.IJEM_412_16.
Diani, M., Altomare, G., & Reali, E. (2016). T helper cell subsets in clinical manifestations of psoriasis. J. Immunol. Res., 7692024.
Beringer, A., Noack, M., & Miossec, P. (2016). IL-17 in chronic inflammation: From discovery to targeting. Trends Mol. Med., 22, 230-241.
Li, D., Cai, W., Gu, R., Zhang, Y., Zhang, H., & Tang, K. (2013). Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin. Immunol., 149, 411-420.
Qin, Q., Liu, P., Liu, L., Wang, R., Yan, N., & Yang, J. (2012). The increased but non-predominant expression of Th17- and Th1-specific cytokines in Hashimoto's thyroiditis but not in Graves' disease. Braz. J. Med. Biol. Res., 45, 1202-1208.
Konca, D. C., Aktas,Y. B., Balos, T. F., Kalkanci, A, & Turhan, I. O, & Fidan, I. (2016). Circulating Th17 cytokine levels are altered in Hashimoto's thyroiditis. Cytokine, 80, 13-17.
Hemdan, N.Y., Birkenmeier, G., Wichmann, G., Abu El-Saad, A.M., Krieger, T., & Conrad, K. (2010). Interleukin-17-producing T helper cells in autoimmunity. Autoimmun. Rev., 9,785-792.
Yu, Z., Liu, T., & Liu, S. (2015). Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. Int. J. Mol. Med., 35, 413-424.
Jung, J.H., Song, G.G., Kim, J-H., & Choi, S.J. (2016). Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta-Analysis. Human Immunology, 84(5), 272-277. DOI: 10.1111/sji.12470.
Díez, J.J., Hernanz, A., Medina, S., Bayón, C., & Iglesias, P. (2002). Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function. Clin. Endocrinol. (Oxf.), 57(4), 515-521. DOI: 10.1046/j.1365-2265.2002.01629.x.
Siemińska, Lucyna, Wojciechowska, Celina, Kos-Kudła, Beata, Kajdaniuk, Marek Bogdan, Dariusz, Nowak, Mariusz, Głogowska-Szelag, Joanna, … Strzelczyk, Janusz (2010). Serum concentrations of leptin, adiponectin, and interleukin-6 in postmenopausal women with Hashimoto's thyroiditis. Endokrynol. Pol., 61(1), 112-116.
El-Shenawy, S.Z., Hemi, M.H., & Attia, H. (2011). Serum Levels of Proinflammatory Cytokines (Interleukin 6 & Interleukin 15) and Adiponectin in Hashimoto’s Thyroiditis with Different Thyroid Function States. J. American Science, 7(6), 1156-1162.
Marchiori, R.C., Pereira, L.A., & Naujorks, A. (2015). Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment. BMC Endocr. Disord., 15(32), 1-9.
Sahar, H.A.Al-Hindawi (2019). Analysis of Serum Il-6 and CRP Levels among Autoimmune and Non-Autoimmune Hypothyroid Patients. Indian Journal of Public Health Research and Development, 10(4), 1439-1445.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
