COMORBIDITIES IN HOSPITALIZED PATIENTS WITH CORONAVIRUS DISEASE AND LUNG DAMAGE: FOCUS ON KIDNEY DYSFUNCTION
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i4.13313Keywords:
coronavirus disease, COVID-19, comorbidity, renal dysfunction, creatinineAbstract
SUMMARY. The severity and course of coronavirus disease (COVID 19) depend on age, background disease, immune response activity, and strain of the virus itself. The structure of premorbid pathology in hospitalized patients with COVID-19 and lung damage is presented in paper and the frequency of comorbid diseases in groups with normal and impaired renal function is analyzed.
The aim – to study the structure of premorbid pathology in hospitalized patients with COVID-19 with lung damage. Compare the incidence of comorbid conditions in patients with COVID-19 and renal dysfunction.
Material and Methods. 243 patients with COVID-19 and pulmonary lesions were examined. The diagnosis of
COVID-19 was verified by polymerase chain reaction, and lung damage was confirmed by radiological methods. Comparison of groups was carried out according to the Mann-Whitney test, correlation analysis was performed by calculating the Spearman correlation coefficient. Relative values are presented as a percentage, the groups were compared by Pearson's criterion c2.
Results. Among the hospitalized patients with COVID-19 and pulmonary lesions, cardiovascular pathology, type 2 diabetes mellitus and their complications were the main diseases.
In the group of patients with normal renal function, 20.3 % of patients were without concomitant pathology, while in the group with impaired renal function, only 10 % had no other diseases. The proportion of patients with one, two or four comorbid conditions did not differ between groups, but the combination of three comorbidities was almost twice as common among patients with renal dysfunction. Most often it is a combination of hypertension, coronary heart disease and diabetes mellitus type 2.
Conclusions. The most common background diseases in hospitalized patients with COVID-19 and lung damage were hypertension – 70,0 %, coronary heart disease – 44.9 %, diabetes mellitus type 2 – 22.2 %. Among patients with renal dysfunction during COVID-19, the combination of 3 comorbidities was significantly more common (p=0.03), while without comorbidities there were twice as many patients (10.0 % vs 20.0 %, p<0.01). In the comorbidity structure, the incidence of hypertension and coronary heart disease was significantly higher compared with patients with normal renal function.
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