VASCULAR ENCEPHALOPATHY: SOME FEATURES OF CEREBRAL HEMODYNAMICS
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i2.13140Keywords:
hydrocephalus, chronic brain ischemia, hemodynamicsAbstract
SUMMARY. The study of hemodynamic parameters, elucidation of their connection with cognitive disorders, age and sex contributes to the improvement of diagnostic approaches and optimization of vascular encephalopathy prognosis.
The aim – to identify the features of hemodynamic parameters in patients with VE in combination with HC.
Material and Methods. A comprehensive examination of 140 patients with VE and HC was carried out. The presence of HC, Montreal cognitive test data, age and sex of the subjects were taken into account. Studies of cerebral blood flow were studied using TCDS of intracranial and extracranial vessels on a Philips HDI device. Computed tomography of the brain was evaluated with subsequent determination of morphometric parameters and indices. The Statistica program was used for statistical processing of results.
Results. It was found that in patients with VE with HC, there was a significantly larger diameter of both ECA, the thickness of CIM, FDS, PSS, and IR of the left artery (p<0.05) compared with patients with VE without HC. We found the following correlations in patients with VE with HC: PSS MBA/MOCA (r=0.39, p<0.05), PSS ABA/MOCA (r=0.30, p<0.05), diameter of PBA/MOCA (r=-0.31, p<0.05). Decreased or significantly, increased diameter of cerebral arteries is usually associated with the state of the brain parenchyma and its function and may have a direct impact on cognitive function. The relationships between the condition of cerebral vessels and morphometric parameters of the brain, were found: CIM/BFI (r=0.33, p<0.05), CIM/right LV (r=0.36, p<0.05), IR MBA/BCI (r=0.32, p<0.05), IR ABA/IFH (r=0.34, p<0.05). There is no significant difference between most functional parameters of extra and intracranial blood flow depending on the sex of the patient. It was found that the diameter of the CCA and the thickness of the CIM, in addition, were significantly different in patients 45–59 years compared with patients aged 60 to 74 years (p<0.05).
Conclusions. The relationship between morphometric parameters, which indicate subcortical and cortical cerebral atrophy, the severity of cognitive deficits, age and sex, depending on the state of hemodynamics.
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