DISORDERS OF COGNITIVE FUNCTIONS IN CHRONIC DISEASES OF THE RESPIRATORY ORGANS
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i2.13127Keywords:
cognitive impairment, COPD, bronchial asthmaAbstract
SUMMARY. Bronchial asthma and chronic obstructive pulmonary disease (COPD) are among the factors in the development of cognitive impairment.
In the world today there is a threatening increase in the prevalence of cognitive disorders. With the current speed of progress and development of new technologies, it is difficult to underestimate how the violation of certain brain functions can affect human life and society as a whole. The combination of these pathologies directly affects the patient, impairing his health, household and social activities, and places a significant burden on the health care system and society as a whole.
The aim – to analyze the literature and formulate conclusions about the current state of research in cognitive disorders in chronic diseases of the respiratory system.
Main part. Chronic respiratory disease is associated with an almost double risk of mild cognitive impairment. Even patients with mild to moderate asthma and COPD have high levels of cognitive dysfunction. Cognitive functions such as psychomotor speed, information processing, attention, concentration and memory are most affected.
The main pathogenetic mechanisms in the development of cognitive disorders are vascular-mediated pathology of the brain, oxidative stress, hypoxemia and decreased physical activity. Mild and moderate cognitive impairment is a potentially reversible condition, with the timely detection and correction of which is likely to return to normal cognitive function in patients with chronic respiratory disease.
Conclusions. The negative impact of cognitive impairment on health and daily life in patients with chronic respiratory diseases, shows the need to assess the functions of the cognitive sphere in patients with chronic respiratory diseases to prevent dementia, improve quality of life and social activity, reduce hospitalizations and mortality.
The presence of cognitive impairment in patients with COPD or bronchial asthma requires an individual approach, comprehensive diagnosis and treatment, taking into account both existing pathologies.
References
Forum of International Respiratory Societies. The Global Impact of Respiratory Disease – Second Edition. Sheffield, European Respiratory Society, 2017 – 43 p. – URL: https://www.who.int/gard/ publications/The_ Global_Impact_of_Respiratory_Disease.pdf.
Eisner M. An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease / M. Eisner, N. Anthonisen, D. Coultas // Am. J. Respir. Crit. Care Med. – 2010. – Vol. 182. – P. 693–718.
Assessing national capacity for the prevention and control of noncommunicable diseases: report of the 2019 global survey. – Geneva: World Health Organization. – 2020. – 101 p. – URL: https://www.who.int/publications/i/item/ncd-ccs-2019.
Опімах С. Г. Якість життя хворих на хронічне обструктивне захворювання легень з порушеннями газообміну / С. Г. Опімах, С. М. Москаленко, Н. В. Крамарська // Астма та алергія. – 2015. – №4. – С. 28–32.
COPD and cognitive impairment / D. Lawi, G. Berra, J. Janssens, P. M. Soccal, D. Adler // Rev. Med. Suisse. – 2018. – Vol. 4. – P. 2066–2069.
Somatic factors in cognitive impairment / T. Etgen, D. Sander, H. Bickel, K. Sander // Fortschr. Neurol. Psychiatr. – 2009. – Vol. 77 (2). – P. 72–82.
Яхно Н. Н. Когнитивные расстройства / Н. Н. Яхно // Неврологический вестник. – 2007. – № 1. – С. 134–138.
Козьолкін О. А. Алгоритм діагностики та лікування деменції : навч. посіб. для самостійної роботи лікарів-інтернів за спеціальністю «Неврологія», «Психіатрія», «Загальна практика – сімейна медицина», лікарів-неврологів, сімейних лікарів / О. А. Козьолкін, А. В. Ревенько, С. О. Мєдвєдкова. – Запоріжжя : ЗДМУ, 2021. – 96 с.
Мудренко І. Г. Клінічні предиктори суїцидальної поведінки хворих з деменціями різних типів / І. Г. Мудренко // Журнал клінічних та експериментальних досліджень. – 2018. – № 1. – C. 89–96.
Деменція : навчально-методичний посібник / О. А. Козьолкін, М. В. Сікорська, І. В. Візір, Ю. М. Нерянова. – Запоріжжя : ЗДМУ, 2015. – 90 с.
Приходько В. Ю. Проблема когнітивних порушень у практиці сімейного лікаря / В. Ю. Приходько, І. Р. Мікропуло // Ліки України. – 2014. – № 7. – С. 23–28.
Дамулин И. В. Когнитивные нарушения при поражении мелких церебральных сосудов / И. В. Дамулин // Consilium medicum. – 2015. – №. 9. – С. 10–16.
Chang S. S. Effect of coexisting chronic obstructive pulmonary disease and cognitive impairment on health outcomes in older adults / S. S. Chang, S. Chen // J. Am. Geriatr. Soc. – 2012. – Vol. 60 (10). – P. 1839–1846.
Depressiveness, symptoms of anxiety and cognitive dysfunctions in patients with asthma and chronic obstructive pulmonary disease (COPD): possible associations with inflammation markers: a pilot study / A. Bratek, K. Zawada, J. Beil-Gawełczyk [et al.] // J. Neural. Transm. (Vienna). – 2015. – Vol. 122 (1). – P. 83–91.
Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study / M. Rusanen, T. Ngandu, T. Laatikainen [et al.] // Curr. Alzheimer. Res. – 2013. – Vol. 10 (5). – P. 549–555.
Adult asthma increases dementia risk: a nationwide cohort study / Y. H. Peng, B. R. Wu, C. H. Su [et al.] // J. Epidem. Community Health. – 2015. – Vol. 69. – P. 123–128.
Cognitive impairment in patients with COPD: a review / F. A. Cleutjens, D. J. Janssen, C. Gijsen [et al.] // J. Geront. and Geriatr. – 2014. – Vol. 45 (1). – P. 1–9.
Domain-specific cognitive impairment in patients with COPD and control subjects / F. A. Cleutjens, F. M. Franssen, M. A. Spruit [et al.] // Int. J. Chron. Obstruct. Pulmon. Dis. – 2016. – Vol. 12. – P. 1–11.
Поясник І. М. Клінічна характеристика когнітивних порушень у пацієнтів із хронічним обструктивним захворюванням легень / І. М. Поясник // Міжнародний неврологічний журнал. – 2014. – № 7. – С. 31–34.
Lung function impairment and the risk of incident dementia: The Rotterdam Study / T. Xiao, S. R. Wijnant, S. Licher [et al.] // J. Alzheimers Dis. – 2021. – Vol. 82 (2). – P. 621–630.
Relationship between asthma and cognition: the Cooper Center Longitudinal Study / G. Caldera-Alvarado, D. A. Khan, L. F. Defina, A. Pieper // Allergy. – 2013. – Vol. 68 (4). – P. 545–548.
Dodd J. W. Cognitive function in COPD / J. W. Dodd, S. V. Getov, P. W. Jones // Eur. Respir. J. – 2010. – Vol. 35 (4). – P. 913–922.
Cognitive-pulmonary disease / F. A. Cleutjens, D. J. Janssen, R.W. Ponds, J. B. Dijkstra, E. F. Wouters // Biomed. Res. Int. –2014. – Vol. 1 – P. 69–78.
Гонгальский В. В. О возможности регуляции венозного оттока из глубоких структур головного мозга / В. В. Гонгальський, Е. В. Прокопович // Журнал неврологии и психиатрии им. С. С. Корсакова. – 2005. – № 5. – С. 62–63.
COPD and cognitive impairment: the role of hypoxemia and oxygen therapy / N. Thakur, P. D. Blanc, L. J. Julian [et al.] // Int. J. Chron. Obstruct. Pulmon. Dis. – 2010. – Vol. 5. – P. 263–269.
Integrity Disruptions Correlate With Cognitive Impairments in Asthma / R. Bian, Y. Zhang, Y. Yang [et al.] // J. Magn. Reson. Imaging. – 2018. – Vol. 48. – P. 748–756.
Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression / Y. Lu, S. Zhou, C. Fan [et al.] // J. Asthma. – 2020 – Vol. 2. – P. 1–15.
Hippocampal volume in patients with asthma: Results from the Dallas Heart Study / S. M. Carlson, J. Kim, D. A. Khan [et al.] // J. Asthma. – 2017. – Vol. 54 (1). – P. 9–16.
Leupoldt A. Structural brain changes related to disease duration in patients with asthma / A. Leupoldt, S. Brassen // PLOS One. – 2011. – Vol. 6 (8). DOI : 10.1371/journal.pone.0023739.
Bozek A. The improvement of cognitive functions in patients with bronchial asthma after therapy / A. Bozek, J. Krajewska, J. Jarzab // J. Asthma. – 2010. – Vol. 47 (10). – P. 1148–1152.
COPD patients' self-reported adherence, psychosocial factors and mild cognitive impairment in pulmonary rehabilitation / A. Pierobon, E. Bottelli, L. Ranzini, [et al.] // Int. J. Chron. Obstruct. Pulmon. Dis. – 2017. – Vol. 12. –
P. 2059–2067.
Dodd J. W. Lung disease as a determinant of cognitive decline and dementia / J. W. Dodd // Alzheimer’s Res. Ther. – 2015. – Vol. 7 (1). – P. 32–40.
REFERENCES
Forum of International Respiratory Societies. (2017). The Global Impact of Respiratory Disease – Second Edition. Sheffield, European Respiratory Society. Retrieved from: https://www.who.int/gard/publications/The_ Global_Impact_of_Respiratory_Disease.pdf.
Eisner, M., Anthonisen, N., & Coultas, D. (2010). An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 182, 693-718.
Assessing national capacity for the prevention and control of noncommunicable diseases: report of the 2019 global survey. (2020). Geneva. World Health Organization. Retrieved from: https://www.who.int/publications/i/item/ncd-ccs-2019.
Opimakh, S.H., Moskalenko, S.M., & Kramarska, N.V. (2015). Yakist zhyttia khvorykh na khronichne obstruktyvne zakhvoriuvannia lehen z porushenniamy hazoobminu [Quality of life of patients with chronic obstructive pulmonary disease with gas exchange disorders]. Astma ta alerhiia – Asthma and Allergy, 4, 28-32 [in Ukrainian].
Lawi, D., Berra, G., Janssens, J., Soccal, P.M., & Adler, D. (2018). COPD and cognitive impairment. Rev. Med. Suisse., 4, 2066-2069.
Etgen, T., Sander, D., Bickel, H., & Sander, K. (2009). Somatic factors in cognitive impairment. Fortschr. Neurol. Psychiatr., 77 (2), 77-82.
Yakhno, N.N. (2007). Kognitivnye rasstrojstva [Cognitive disorders]. Nevrologicheskij vestnik – Neurological Bulletin, 1, 131-138 [in Russian].
Kozolkin, O.A., Revenko, A.V., & Miedviedkova, S.O. (2021). Alhorytm diahnostyky ta likuvannia dementsii : navch. posib. dlia samostiinoi roboty likariv-interniv za spetsialnistiu «Nevrolohiia», «Psykhiatriia», «Zahalna praktyka – simeina medytsyna», likariv-nevrolohiv, simeinykh likariv [Algorithm for diagnosis and treatment of dementia: a textbook for independent work of interns in the specialty "Neurology", "Psychiatry", "General practice - family medicine", neurologists, family doctors]. Zaporizhzhia: ZDMU [in Ukrainian].
Mudrenko, I.H. (2018). Klinichni predyktory suitsydalnoi povedinky khvorykh z dementsiiamy riznykh typiv [Clinical predictors of suicidal behavior in patients with dementias of different type]. Zhurnal klinichnykh ta eksperymentalnykh doslidzhen – Journal of Clinical and Experimental Research, 1, 89-96 [in Ukrainian].
Kozolkin, O.A., Sikorska, M.V. Vizir, I.V., & Nerianova, Yu.M. (2015). Dementsiia: navchalno-metodychnyi posibnyk [Dementia: educational and methodical textbook]. Zaporizhzhia: ZDMU [in Ukrainian].
Prykhodko, V.Yu., & Mikropulo, I.R. (2014). Problema kohnityvnykh porushen u praktytsi simeinoho likaria [The problem of cognitive disorders in the practice of general practitioner]. Liky Ukrainy – Medicines of Ukraine, 7, 23-28 [in Ukrainian].
Damulin, I.V. (2015). Kognitivnye narusheniya pri porazhenii melkikh cerebralnykh sosudov [Cognitive impairment in the defeat of small cerebral vessels]. Consilium Medicum, 9, 10-16 [in Russian].
Chang, S.S., & Chen, S. (2012). Effect of coexisting chronic obstructive pulmonary disease and cognitive impairment on health outcomes in older adults. J. Am. Geriatr. Soc, 60 (10), 1839-1846.
Bratek, A., Zawada, K., Beil-Gawełczyk, J., Beil, S., Sozańska, E., Krysta, K., & Barczyk, A. (2015). Depressiveness, symptoms of anxiety and cognitive dysfunctions in patients with asthma and chronic obstructive pulmonary disease (COPD): possible associations with inflammation markers: a pilot study. J. Neural. Transm. (Vienna),122 (1), 83-91.
Rusanen, M., Ngandu, T., Laatikainen, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2013). Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study. Curr. Alzheimer. Res.,10 (5), 549-555.
Peng, Y.H., Wu, B.R., Su, C.H., Liao, W.C., Muo, C.H., Hsia, T.C., & Kao, C.H. (2015). Adult asthma increases dementia risk: a nationwide cohort study. J. Epidem. Community Health., 69, 123-128.
Cleutjens, F.A., Janssen, D.J., Gijsen, C., Dijkstra, .B., Ponds, R.W., & Wouters, E.F. (2014). Cognitive impairment in patients with COPD: a review. J. Geront. and Geriatr., 45 (1), 1-9.
Cleutjens, F.A., Franssen, F.M., Spruit, M.A., Vanfleteren, L.E., Gijsen, C., Dijkstra, J.B., Ponds, R.W., Wouters, E.F. & Janssen, D.J. (2016) Domain-specific cognitive impairment in patients with COPD and control subjects. Int. J. Chron. Obstruct. Pulmon. Dis., 12, 1-11.
Poiasnyk, I.M. (2014). Klinichna kharakterystyka kohnityvnykh porushen u patsiientiv iz khronichnym obstruktyvnym zakhvoriuvanniam lehen [Clinical characteristics of cognitive impairment in patients with chronic obstructive pulmonary disease]. Mizhnarodnyi nevrolohichnyi zhurnal – International Journal of Neurology, 7, 31-34.
Xiao, T., Wijnant, S.R., Licher, S., Terzikhan, N., Lahousse, L., Ikram, M.K., Brusselle, G.G., & Ikram M.A. (2021) Lung function impairment and the risk of incident dementia: The Rotterdam Study. J. Alzheimers Dis., 82 (2), 621-630.
Caldera-Alvarado, G., Khan, D.A., Defina, L.F., & Pieper, A. (2013). Relationship between asthma and cognition: the Cooper Center Longitudinal Study. Allergy, 68 (4), 545-548.
Dodd, J.W., Getov, S.V., & Jones, P.W. (2010). Cognitive function in COPD. Eur. Respir. J., 35 (4), 913-922.
Cleutjens, F.A., Janssen, D.J., Ponds, R.W., Dijkstra, J.B., & Wouters, E.F. (2014). Cognitive-pulmonary disease. Biomed. Res. Int., 1, 69-78.
Gongalskij, V.V., & Prokopovich, E.V. (2005). O vozmozhnosti regulyatsii venoznogo ottoka iz glubokikh struktur golovnogo mozga [On the possibility of regulating venous outflow from deep brain structures] Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova – Journal of Neurology and Psychiatry S. S. Korsakov, 5, 62-63 [in Russian].
Thakur, N., Blanc, P.D., Julian, L.J., Yelin, E.H., Katz, P.P., Sidney, S., Iribarren, C., & Eisner, M.D. (2010). COPD and cognitive impairment: the role of hypoxemia and oxygen therapy. Int. J. Chron. Obstruct. Pulmon. Dis., 5, 263-269.
Bian, R., Zhang, Y., Yang, Y., Yin, Y., Zhao, X., Chen, H., & Yuan Y.J. (2018). Integrity Disruptions Correlate With Cognitive Impairments in Asthma. J. Magn. Reson. Imaging., 48, 748-756.
Lu, Y., Zhou, S., Fan, C., Li, J., Lian, Y., & Shang, Y. (2020). Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression. J. Asthma, 2, 1-15.
Carlson, S.M., Kim, J., Khan, D.A., King, K., Lucarelli, R.T., Peshock, R., & Brown, E.S. (2017). Hippocampal volume in patients with asthma: Results from the Dallas Heart Study. J. Asthma, 54 (1), 9-16.
Leupoldt, A., & Brassen, S. (2011). Structural brain changes related to disease duration in patients with asthma. PLOS One, 6 (8). DOI : 10.1371/journal.pone.0023739.
Bozek, A., Krajewska, J., & Jarzab, J. (2010) The improvement of cognitive functions in patients with bronchial asthma after therapy. J. Asthma, 47 (10), 1148-1152.
Pierobon, A., Bottelli, E., Ranzini, L., Bruschi, C., Maestri, R., Bertolotti, G., Sommaruga, M., Torlaschi, V., Callegari, S., & Giardini, A. (2017). COPD patients' self-reported adherence, psychosocial factors and mild cognitive impairment in pulmonary rehabilitation. Int. J. Chron. Obstruct. Pulmon. Dis., 12, 2059-2067.
Dodd, J.W. (2015). Lung disease as a determinant of cognitive decline and dementia. Alzheimer’s Res. Ther., 7 (1), 32-40.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
