MULTIPLE PREGNANCIES AFTER USE OF ART: ITS RISKS, COMPLICATIONS, GESTATIONAL AGE AND RESULTS

Authors

  • M. O. Franchuk I. Horbachevsky Ternopil National Medical University
  • O. A. Franchuk I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/1811-2471.2022.v.i2.13012

Keywords:

premature birth, obstetrical pessary

Abstract

SUMMARY. Multiple pregnancy is a pregnancy when a woman develops two or more fetuses. Multiple pregnancy is a high-risk pregnancy and belongs to the section of pathological obstetrics due to the risk of adverse effects on the mother and fetus. In the last 15–20 years, the frequency of multiple pregnancy and childbirth is progressively increasing, due to the widespread introduction of treatment for various forms of infertility, as well as the use of assisted reproductive technologies (ART). One of the most difficult problems to solve in multiple births - is frequent, and perhaps predominant, childbirth before 37 weeks of pregnancy. Due to the widespread and progressive introduction of ART in modern obstetrics, the incidence of multiple births will continue to grow. Therefore, early diagnosis of multiple pregnancy, prevention and elimination of obstetric complications during pregnancy and childbirth are the main tasks in addressing the reduction of perinatal losses and maternal pathologies in multiple births.

The aim – to study and analyze the anamnestic features, the frequency of obstetric and perinatal complications in women with multiple pregnancies after the use of ART, which was not carried out (due to patient refusal) prevention of abortion by establishing an obstetrical pessary.

Material and Methods. Analyzed anamnestic features, pregnancy, childbirth, postpartum period and the condition of newborns in 35 women with multiple pregnancy after ART and who did not have an obstetrical pessary for prophylactic purposes due to patients' refusal of this manipulation. Clinical examination methods, standard laboratory examinations and transvaginal cervicometry were performed.

Results. We obtained the results of analysis of somatic and social history in women, identified number of extragenital diseases in pregnant women with multiple births, studies of their gestational age and childbirth, assessment of newborns, indicating a high frequency of various gestational complications in women with multiple births, frequent premature birth, as well as a high risk of antenatal and perinatal complications and losses.

Conclusions. According to the results, it was found that women with multiple pregnancy in our study group had a high percentage of gestational complications, premature birth and, consequently, the birth of children with low body weight with subsequent consequences in the postnatal period.

References

Nakaz MOZ Ukrainy № 205 vid 08.04.2015 r. «Pro zatverdzhennia Poriadku nadannia medychnoi dopomohy zhinkam z bahatoplidnoiu vahitnistiu» [ Order of the Ministry of Health of Ukraine “On approval of the Procedure for providing medical care to women with multiple pregnancies”]. Retrieved from: https://zakon.rada.gov.ua/laws/show/z0501-15#Text [in Ukrainian].

Tkachenko, A.V. (2018). Bahatoplidna vahitnist u suchasnomu akusherstvi (Ohliad literatury). [Multiple pregnancy in contemporary obstetrics (Review of the literature)]. Semeinaia medytsyna – Family Medicine, 1, 116-120. Retrieved from: http://nbuv.gov.ua/UJRN/simmed_2018_1_24 [in Ukrainian].

Dykusarova, S.M., Platonova, O.M., & Khylobok-Yakovenko, O.V. (2018). Perynatalni vyslidy bahatoplidnoi vahitnosti pislia zaplidnennia in vitro ta pry spontannykh vahitnostiakh [Perinatal outcomes of multiple gestation after in vitro fertilization and spontaneous pregnancies]. Perynatolohiia ta pediatriia – Perinatology and Pediatrics, 1, 70-73. DOI: 10.15574/PP.2018.73.70 [in Ukrainian].

Fuchs, F., Monet, B., Ducruet, T., Chaillet, N., & Audibert, F. (2018). Effect of maternal age on the risk of preterm birth: A large cohort study. PloS One, 13(1), e0191002. DOI: 10.1371/journal.pone.0191002.

Crump, C. (2020). Preterm birth and mortality in adulthood: a systematic review. Journal of Perinatology : Official Journal of the California Perinatal Association, 40(6), 833-843. DOI: 10.1038/s41372-019-0563-y.

Nikitina, I.M., Kalashnyk, N.V., Babar, T.V., & Bolotna, M.A. (2017). Optymizatsiia taktyky vedennia bahatoplidnoi vahitnosti ta polohiv. [Optimization of tactics of management of multiple pregnancy and labor]. Klinichna ta eksperymentalna patolohiia – Clinical and Eksperimental Patology, 16, 4, 63-69. Retrieved from: http://nbuv.gov.ua/UJRN/kep_2017_16_4_14 [in Ukrainian].

Park, S., Lee, S.M., Park, J.S., Hong, J.S., Chin, H.J., Na, K.Y., …, & Lee, H. (2018). Gestational Estimated Glomerular Filtration Rate and Adverse Maternofetal Outcomes. Kidney & Blood Pressure Research, 43(5), 1688-1698. DOI: 10.1159/000494746

Nikitina, I.M., & Sukhariev, A.B. (2017). Suchasni aspekty antenatalnoho nahliadu pry bahatoplidnii vahitnosti. [Modern aspects of antenal observation in multiple pregnancy]. Zhurnal klinichnykh ta eksperymentalnykh medychnykh doslidzhen – Journal of Clinical and Experimental Medical Research., 5(2), 813-822. Retrieved from: http://nbuv.gov.ua/UJRN/VSU_med_2017_5_2_11 [in Ukrainian].

Magee, L.A., & von Dadelszen, P. (2018). State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy. Mayo Clinic proceedings, 93(11), 1664-1677. DOI: 10.1016/j.mayocp.2018.04.033.

Suff, N., Story, L., & Shennan, A. (2019). The prediction of preterm delivery: What is new? Seminars in Fetal & Neonatal Medicine, 24(1), 27-32. Doi.org/10.1016/j.siny.2018.09.006.

Glover, A.V., & Manuck, T.A. (2018). Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: A review. Seminars in Fetal & Neonatal Medicine, 23(2), 126-132. DOI: 10.1016/j.siny.2017.11.007.

Nikitina, I., Boiko, V., Kalashnyk, N., Babar, T., Ikonopystseva, N., Boiko, A., & Bolotna, M. (2019). Porivnialna otsinka efektyvnosti profilaktychnoi interventsii u zhinok z bahatoplidnistiu za umovy bezsymptomnoho vkorochennia shyiky matky. [Comparative estimation of the efficiency of preventive intervention in women with multiple pregnancy with asymptomatic cutting neck of uterus]. Zbirnyk naukovykh prats asotsiatsii akusheriv-hinekolohiv Ukrainy – Collection of scientific practices of the association of obstetricians-gynecologists of Ukraine., 2 44, 81-90. Retrieved from: http://nbuv.gov.ua/UJRN/znpaagu_2019_2_15 [in Ukrainian].

Conde-Agudelo, A., Romero, R., & Nicolaides, K.H. (2020). Cervical pessary to prevent preterm birth in asymptomatic high-risk women: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology, 223(1), 42-65.e2. DOI: 10.1016/j.ajog.2019.12.266.

Roman, A., Zork, N., Haeri, S., Schoen, C.N., Saccone, G., Colihan, S., Zelig, C., Gimovsky, A.C., Seligman, N.S., Zullo, F., & Berghella, V. (2020). Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial. American Journal of Ostetrics and Gynecology, 223(6), 902.e1–902.e11. DOI: 0.1016/j.ajog.2020.06.047.

Kalashnyk, N.V., Nikitina, I.M., & Kondratiuk, V.K. (2017). Adekvatna korektsiia postnatalnykh uskladnen pry bahatoplidnii vahitnosti. [Adequate correction of postnatal complications in multiple pregnancy]. Bukovynskyi medychnyi visnyk – Bukovinian Medical Bulletin, 21, 1, 58-62. Retrieved from: http://nbuv.gov.ua/UJRN/bumv_2017_21_ 1_14 [in Ukrainian].

Published

2022-08-29

How to Cite

Franchuk, M. O., & Franchuk, O. A. (2022). MULTIPLE PREGNANCIES AFTER USE OF ART: ITS RISKS, COMPLICATIONS, GESTATIONAL AGE AND RESULTS. Achievements of Clinical and Experimental Medicine, (2), 153–158. https://doi.org/10.11603/1811-2471.2022.v.i2.13012

Issue

Section

Оригінальні дослідження