EFFECTIVNESS OF THE USE OF COMPLEX OF ALGINATE AND HYALURONIC ACID AIN THE COMPOSITION OF THE COMPLEX THERAPY IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE AND SPINAL INJURIES OF DEGENERATIVE-DYSTROPHIC AND INFLAMMATORY GENESIS
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i1.12999Keywords:
gastroesophageal reflux disease, osteochondrosis, spondyloarthritis, treatment, alginate, hyaluronic acidsAbstract
SUMMARY. The search of alternative treatment regimens for patients with gastroesophageal reflux disease (GERD), especially in combination with diseases that require long-term use of drugs from the group of nonsteroidal anti-inflammatory drugs is an urgent problem of modern clinical medicine.
The aim – to determine the features of the dynamics of the clinical course of GERD in patients with spinal degenerative-dystrophic and inflammatory genesis on the background of complex therapy using a complex of alginate and hyaluronic acids.
Material and Methods. 126 patients with GERD with various forms of spinal cord injury were examined. Patients with GERD were divided into 2 groups: group I included 46 patients with osteochondrosis (OC) of the cervical and thoracic spine, and group II consisted of 50 patients with spondyloarthritis (SpA) of the spine. All examined patients underwent general clinical studies. Depending on the method of treatment, patients were divided into subgroups: patients 1.2 subgroups (n=44) and 2.2 subgroups (n=40) received only basic therapy (BT), and patients 1.2 subgroups (n=44) and 2.2 subgroups (n=40) in addition to BT, a complex of alginate and hyaluronic acid was prescribed for 1 month.
Results. In patients with OС and SpA, complex therapy with alginate and hyaluronic acid based on the clinical manifestations of GERD was more effective, which led to a decrease in the severity of esophageal manifestations of GERD (heartburn, acid regurgitation, dysphagia), as well as atypical clinical signs of reflux. dental, otolaryngological, bronchopulmonary and cardiac). Also, additional administration of alginate and hyaluronic acids helped to reduce the severity of endoscopic changes in the esophageal mucosa (EM), namely a decrease in the number of patients in subgroups 1.2 and 2.2 of LA-D and LA-C, accompanied by an increase in LA-A (p<0.05).
Conclusions. GERD in patients with osteochondrosis of the cervical and thoracic spine is clinically more often manifested by esophageal symptoms, while in patients with spondyloarthritis – extraesophageal symptoms (dental, otolaryngological, cardiac, broncho-pulmonary manifestations). Defeat of EM in endoscopic examination in patients with degenerative-dystrophic changes of the spine more often corresponds to LA-B, as in patients with spondyloarthritis – LA-B (especially in patients with atypical clinical course of GERD). Combination therapy with alginate and hyaluronic acid (Hialera) is a more effective method for the dynamics of clinical symptoms and showed EM lesions in endoscopic examination than BT, which includes a proton pump inhibitor and itopride hydrochloride.
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