DYNAMICS OF LIVER FUNCTIONAL ACTIVITY INDICATORS DURING LATE MANIFESTATIONS OF CRANIOSKELETAL TRAUMA UNDER CONSTITUTIONAL CHRONIC CHEOPHETIC HEPATHEPHETIS

Abstract

SUMMARY.  Cranioskeletal trauma in the structure of mortality is one of the first in the world. Against this background, the influence of concomitant pathology caused by chronic lesions of the internal organs is insufficiently studied. Of considerable interest is the problem of chronic diffuse liver damage. Therefore, the search for patterns of liver dysfunction and the development of ways to prevent and correct it in the face of severe combined trauma and chronic liver disease is one of the current problems of modern theoretical and practical medicine.

The aim – to determine the dynamics of indicators of functional activity of the liver in the period of late manifestations of cranioskeletal trauma in concomitant chronic hepatitis and to evaluate the effectiveness of armadin correction.

Material and Methods. Cranioskeletal trauma, chronic hepatitis, and combinations were simulated in separate groups of nonlinear white male rats. Armadin at a dose of 20 mg/kg intraperitoneally was used to correct the group with combined lesions. At 14, 21, 28, and 35 days after trauma to the liver of the experimental animals, the rate of bile excretion, the amount of total bile acids, total and conjugated bilirubin in the bile was determined, and the degree of bilirubin conjugation was calculated.

Results. Cranioskeletal injury after 14 days of the post-traumatic period compared with the control is accompanied by a significant decrease in the rate of bile excretion, the content of total bile acids in the bile and the degree of conjugation of bilirubin, which reached the control level by 35 days. At the same time, trauma on the background of concomitant chronic hepatitis also causes a violation of the studied indicators, which is significantly greater than in a group of animals without concomitant chronic hepatitis. The use of armadine under these conditions from the 21st day of the experiment causes a decrease in violations of the studied parameters compared with the group of animals without correction.

Conclusions. Cranioskeletal trauma on the background of chronic hepatitis in the late manifestations of traumatic disease is accompanied by greater impairment of biliary and biliary function of the liver than in the group of injured animals without concomitant liver damage. The use of armadine causes a statistically significant decrease in the intensity of the detected disorders, starting from 21 days of the experiment.