PREDICTION OF 25(OH)D LEVEL IN THE SERUM IN OVERWEIGHT AND OBESE ADOLESCENTS
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i1.12996Keywords:
vitamin D, 25(OH)D, adolescents, adiposity, overweightAbstract
SUMMARY. Vitamin D, due to pleiotropic effects, expresses genes encoding proteins of cell differentiation, apoptosis, regulation of immune processes, lipid and carbohydrate metabolism. Ensuring a sufficient level of vitamin D metabolites in the body prevents the development of metabolic syndrome and cardiovascular pathology.
The aim – to develop on the basis of anthropometric and clinical-anamnestic researches a way of forecasting of provision of vitamin D of children of teenage age.
Material and Methods. 196 adolescent children were examined (76 adolescents with obesity, 60 adolescents with overweight, 60 adolescents with normal body weight). Anthropometric measurements were performed and the body mass index (BMI) and the WC/HC and WC/ height ratio indices were calculated based on their results. Determined enzyme-linked immunosorbent assay in serum level 25(OH)D. Teenagers and / or their parents were interviewed according to the Questionnaire for Assessing Vitamin D Status in Young People.
Results. The level of 25(OH)D in adolescents with normal body weight was 17.90 (12.16–24.93) ng/ml, with excess body weight – 14.69 (10.27–20.30) ng/ml, in obesity –12.71 (9.36–17.37) ng/ml. 25(OH)D is characterized by an inverse correlation with body weight, BMI, WC, HC, WC/HC and WC/height ratios.
It was found that the main predictors that affect the level of vitamin D in obese adolescents include BMI (p=0.003), milk consumption (p=0.006), the use of vitamin D supplements (or fish oil with vitamin D) (p=0.007 ), physical activity (p=0.000).
Conclusions. Adolescents have a low level of vitamin D, which is characterized by significant inverse correlations with the main anthropometric indicators.
The developed equation for determining vitamin D supply, which is based on independent predictors and indicators of anthropometric measurements, can be used by primary care physicians in conducting screening studies and developing ways to prevent vitamin D deficiency.
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