CLOPOGON KITICH (ACTAEA RACEMOSA L.) – A PROMISING SPECIES FOR PHARMACY IN UKRAINE
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i4.12812Keywords:
Actaea racemosa, resources, pharmaceutical market, climacteric disorders, perspectiveAbstract
SUMMARY. Given the growing need for comprehensive research on the development and standardization of domestic herbal remedies for the treatment of menopausal disorders, it is advisable to draw the attention of domestic scientists to the clopogon kitich (Actaea racemose L.), which contains valuable biologically sctive substances – extragens.
The aim – to analyze the herbal remedies and dietary supplements available on the pharmaceutical market of Ukraine, which include A. racemose, to outline the prospects of its cultivation and une in domestic pharmacy.
Material and Methods. The analysis of the pharmaceutical market was carried out using the method of systemic generalization on the based of information screening of materials of the State Register of Medicines, the Register of Medicines of the information retrieval system Compendium online, the catalog of the online store of dietary supplements.
Results. Neurovegetative disorders during menopause and menopausal disorders are a priority for the use of clopogon kitich. The analysis of the pharmaceutical market of Ukraine showed that the range is dominated by solid forms of both herbal remedies (66.7 %) and dietary supplements (77.05 %) containing A. racemosa. The results of the analysis show a significant import of herbal products containing A. racemosa from Western Europe, while the largest number of names of dietary supplements are registered by US manufacturers (96.77 %). Domrstic herbal remedies are represented in small quantities – only 16.67 %. However, the temperate climate and shady terrain typical of the forest-steppe regions of Ukraitine from favorable conditions for growing and providing the resource base of Actaea racemosa L. raw materials for the production of domestic herbal remedies and supplements based on it.
Conclusions. The creation of means of a plant origin and dietary supplements of domestic production on the basis of clopogon kitich is objectively promising, which provides for the feasibility of comprehensive research on its cultivation, in-depth study and standardization of raw materials.
References
Tatarchuk, T.F., & Yefimenko, О.А. (2012). Fitoterapiya rannikh menopauzalnykh rasstroystv [Fitotерerapy for earlymenopausal disorders]. Reproduktivnaia endokrynologia – Reprod. Endocrinol., 5, 41-44 [in Ukrainian].
Compton, J.A., Culham, A., & Jury, S.L. (1998). Reclassification of Actaea to include Cimicifuga and Souliea (Ranunculaceae): phytogeny inferred from morphology, nrDNA ITS, and cpDNA trnL-F sequence variation. Taxon, 47(3), 593-634. DOI: 10.2307/1223580
Tzal, О.Ya. (2016). Poshuk perspektyvnykh dlia doslidzhennia roslyn z rodyny zhovttsevi [Search for promising plants for the study of the Ranunculaceae family]. Proceedings from II Int. Sci.-Pract. Internet conf: Teoretychni ta praktychni aspekty doslidzhennia likarskykh roslyn – Theoretical and practical aspects of research of medicinal plants. Kharkiv [in Ukrainian].
Minarchenko, V.М. (2005). Likarski sudynni roslyny Ukrainy (medychne ta resursne znachennia) [Medicinal vascular plants of Ukraine (medicinal and resours significance)]. Кyiv: Fitosotsiothentr [in Ukrainian].
Mashkovska, S.P. (Ed.). (2015). Katalog dekoratyvnyh travianystyh roslyn botanichnyh sadiv i dendroparkiv Ukrainy [Catalog of ornamental herbaceous plants of botanical gardens and arboretums of Ukraine: a referens guide]. Retrieved from: http://www.nbg.kiev.ua/upload/biblio/katalog.pdf [in Ukrainian].
Doyko, N.M., & Katrevych, M.V. (2019). Adventyvni pivnichnoamerykanski vydy travianykh roslyn u derzhavnomu dendrolohichnomu parku «Oleksandriia» NAN Ukrainy [Adventive North American species of herbaceous plants in the state dendrological park "Alexandria" of the National Academy of Sciences of Ukraine]. Proceedings from III All-Ukr. Sci. Conf.: Synantropizatsiia roslynnoho pokryvu Ukrainy – Synanthropization of vegetation of Ukraine. Kyiv: Nash format [in Ukrainian].
Motina, Ye.А. (2018). Osobennosti sezonnogo razvitiya lekarstvennykh rasteniy semeystva Ranunculaceae v kollektsii farmakopeynogo uchastka botanicheskogo sada VILAR [Features of the seasonal development of medicinal plants of the family Ranunculaceae in the collection of the pharmacopoeial site of the VILAR botanical garden]. Proceedings from VI Int. Conf.: Likarske roslynnythtvo: vid dosvidu mynuloho do novitnikh tekhnolohii – Medicinal vegetation: from past experience to the latest technologies. Poltava [in Ukrainian].
State Enterprise "Ukrainian Scientific Pharmacopoeia Center for the Quality Medicines" (2014). Derzhavna Farmakopeia Ukrainy [State Pharmacopoeia of Ukraine]. Kharkiv : Derzhavne pidpryiemstvo "Ukrayinskyy naukovo-ekspertnyi farmakopeynyi tsentr yakosti likarskykh zasobiv" [in Ukrainian].
Ruhlen, R.L., Sun, G.Y., & Sauter, E.R. (2008). Black Cohosh: Insights into its Mechanism(s) of Action. Integr. Med. Insights., 3, 21-32.
Gromova, О.А., Torshin, I.Yu., Тetruashvili, N.K., Fedotova, L.E., & Laspochkina, N.P. (2018). Molekulyarnyye mekhanizmy osushchestvleniya farmakologicheskikh effektov na osnove Cimicifuga racemose [Molecular mechanisms of the implementation of pharmacological effects based on Cimicifuga racemose]. Ginekologiya – Gynecology, 20(1), 39-46 [in Russian].
Henneicke-von Zepelin H. (2017). 60 years of Cimicifuga racemosa medicinal products: Clinical research milestones, current study findings and current development. 60 Jahre Arzneimittel aus Cimicifuga racemosa: Meilensteine klinischer Forschung, aktuelle Studienergebnisse und derzeitige Entwicklung. Wien Med. Wochenschr., 167(7-8), 147-159. DOI:10.1007/s10354-016-0537-z.
Zieran, O., Bodinet, C., Kolba, S., Wulf, M., & Vollmer G. (2002). Antiestrogenic activities of Cimicifuga racemosa extracts. J. Steroid Biochem. Mol. Biol., 80(1), 125-130. DOI: 10.1016/S0960-0760(01)00178-9.
Borelli, F., Izzo, А., & Ernst, E. (2003). Pharmacological effects of Cimicifuga racemose. Life Science., 73(10), 1215-1229. DOI: 10.1016/S0024-3205(03)00378-3.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
