ADVANTAGES OF THE BIORREGULATORY APPROACH IN THE TREATMENT AND REHABILITATION OF COVID-19 PATIENTS. CLINICAL EXPERIENCE
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i4.12801Keywords:
community-acquired pneumonia associated with COVID-19, complex assessment of a condition of an organism, typical pathological processes, bioregulatory correction, personalized rehabilitation interventionsAbstract
SUMMARY. Since the outbreak of the new coronavirus infection COVID-19 which is caused by SARC-Cov-2 virus, the medical community has been assigned the tasks related not only to providing the qualified medical care but also to rehabilitation interventions during the course of the disease and after the one.
In most cases, mild and even asymptomatic forms of the disease course are observed; moderate manifestations through pneumonia without respiratory failure can be often observed; less often different severity of respiratory failure can be observed and sometimes the course of the disease is complicated by the development of acute respiratory distress syndrome (ARDS). It is the character of the epidemical spread and the heterogeneous disease clinical picture which indicate the significant role of a body functional condition level in the development of this pathology. Therefore, the timely usage of nonspecific methods including physical modalities correcting typical pathological processes, such as inflammation, endogenous intoxication, metabolic disorders, energy balance, immune defense, can prevent the development of complications.
Taking into account the peculiarities of the disease pathogenesis and the variety of clinical forms, the routine usage of generally accepted schemes is often ineffective. And the effectiveness of the methods applied directly depends on the early beginning of rehabilitation interventions including the complex assessment of a patientʼs condition.
Own clinical experience of supervising the geriatric patient with community-acquired pneumonia associated with COVID-19 and the comorbid pathology on the stages of treatment and rehabilitation is presented in this article. This clinical case demonstrated the possibilities, efficiency and safety of the implemented bioregulatory correction personalized algorithm as well as the individual rehabilitation program based on the complex assessment of the patientʼs health.
References
Bolevich, S.B., & Bolevich, S.S. (2020). Kompleksnyy mekhanizm razvitiya COVID-19 [Complex mechanism of COVID-19 development]. Sechenovskiy vestnik – Sechenov Journal, 11(2), 50-61. DOI: https://doi.org/10.47093/2218-7332.2020.11.2.50-61 [in Russian].
Byanchi, I. (2016). Koenzim kompozitum i Ubikhinon kompozitum i ikh rol v poddrezhke funktsiy mitokhondriy [The role Coenzyme compositum and Ubiquinone compositum in support of mitochondrial functions]. Biologicheskaya meditsina – Biological Medicine, 1, 16-24; 27-31 [in Russian].
Girin, S.V. (2013). Kompleksnoye opredeleniye sostoyaniya organizma v praktike semeynogo vracha [Complex determination of the state of the body in the practice of a family doctor]. Biologicheskaya terapiya – Biological Therapy, 1, 30-33 [in Russian].
Girin, S.V., & Yurchenko, I.V. (2010). Integralnyye gematologicheskiye pokazateli v otsenke sostoyaniya organizma [Integral hematological indicators in assessing the state of the body]. Biologicheskaya terapiya – Biological Therapy, 4, 18-21 [in Russian].
(2021). Klinichne vedennia patsiientiv z COVID-19 [Clinical management of patients with COVID-19]. «Zhyva» klinichna nastanova Ministerstva Okhorony Zdorovia Ukrainy, Derzhavnyi Ekspertnyi Tsentr Ministerstva Okhorony Zdorovia Ukrainy, Derzhavna Naukova Ustanova «Naukovo-praktychnyi Tsentr profilaktychnoi i klinichnoi medytsyny» Derzhavnoho Upravlinnia Spravamy – "Live" clinical guidelines of the Ministry of Health of Ukraine, State Expert Center of the Ministry of Health of Ukraine, State Scientific Institution "Scientific and Practical Center for Preventive and Clinical Medicine" of the State Administration. Retrieved from: https://doi.org/10.31612/covid.
Maryanovskiy, A.A. (1998). Biologicheskiye osnovy primeneniya katalizatorov v kompleksnoy terapii khronicheskikh zabolevaniy [Biological bases of the use of catalysts in the complex therapy of chronic diseases]. Biologicheskaya meditsina – Biological Medicine, 2, 31-43 [in Russian].
Smiyan, O.I., Sichnenko, P.I., Moshchуch, O.P., Gorbas, V.A., Girin, S.V., Ivanushko, O.V., & Moshуch, O.O. (2020). Dosvid zastosuvannia alhorytmu kompleksnoi otsinky stanu orhanizmu u ditei z khronichnoiu hastroduodenalnoiu patolohiieiu [Experience in application of the complex organism assessment in children with chronic gastroduodenal pathology]. Eastern Ukrainian Medical Journal, 8(1), 52-71 [in Ukrainian].
(2020). Smiyan, O.I., Sichnenko, P.I., Horbas, V.A., Moshchych, O.P. Pat. Ukrainy, Sposib optymizatsii otsinky zahalnoho stanu zdorovia orhanizmu liudyny za dopomohoiu alhorytmu kompleksnoi otsinky stanu khvoroho na pidstavi analizu typovykh patolohichnykh protsesiv ta funktsionalnykh mozhlyvostei orhanizmu [Patent of Ukraine. The method of optimizing assessment of general health of human body by means of algorithm of complex assessment of patients condition on the basis of analysis of typical pathological processes and functional possibilities of organism]. No. 143026 MPK A 61 B 5/00, G 01 N 33/00; zaiavnyk i patentovlasnyk Sumskyi derzhavnyi universytet. No. u 2019 12205; zaiavl. 24.12.2019; opubl. 10.07.2020, Biul. No. 13 [in Ukrainian].
(2020). Pro zatverdzhennia protokolu «Nadannia medychnoi dopomohy dlia likuvannia koronavirusnoi khvoroby (COVID-19)» [On approval of the protocol "Amendments to the Standards of Medical Care “Coronavirus Disease (COVID19)"]. Nakaz Ministerstva okhorony zdorovia Ukrainy vid 2.04.2020 r. № 762 (v redaktsii nakazu Ministerstva okhorony zdorovia Ukrainy vid 31 hrudnia 2020 roku № 3094) – Order of the Ministry of Health of Ukraine of 2 April 2020 No. 762 – (as amended by the order of the Ministry of Health of Ukraine from 31 December 2020 No. 3094)]. Retrieved from: https://moz.gov.ua/uploads/3/19829-protokol.pdf [in Ukrainian].
Phazylov, V.Kh., Galeeva, N.V., Zagidullina, A.I., & Tairov, I.N. (2013). Ozonoterapiya v klinike infektsionnykh bolezney [Ozone therapy in clinic of infectious diseases]. Prakticheskaya meditsina – Practical Medicine, 5(74), 47-50. Retrieved from: https://cyberleninka.ru/article/n/ozonoterapiya-v-klinike-infektsionnyh-bolezney [in Russian].
Ponomarenko, G.N. (Ed.). (2009). Fizioterapiya: natsionalnoye rukovodstvo [Physiotherapy: national guidance]. Moscow: GEOTAR-Media [in Russian].
Hanferian, R.A., Daihes, N.A., Karneeva, O.V., Garashchenko, T.I., & Kim, I.A. (2019). Protivovirusnyye immunomoduliruyushchiye effekty Engistola [Antiviral and immunomodulatory effects of Engystol]. Meditsinskiy sovet – Medical Council, 8, 116-120. DOI: https://doi.org/ 10.21518/ 2079-701X-2019-8-116-120.
Chursina, T.Ya., & Mikhalev, K.A. (2006). Allopaticheskaya i antigomotoksicheskaya terapiya ostrogo vospaleniya: alternativnyye ili vzaimodopolnyayushchiye puti? [Allopathic and antihomotoxic therapy of acute inflammation: alternative or complementary ways?]. Biologicheskaya Terapiya – Biological Therapy, 1, 17-21 [in Russian].
Shamugiya, B.K., & Timoshkov, M.V. (2013). Vozmozhnosti preparata Traumel S v terapii vospaleniya [Possibilities of Traumeel C in the therapy of inflammation]. Mystetstvo likuvannia – Art of Medicine, 2-3(98-99), 44-49 [in Russian].
Nunn, A.V.W., Guy, G.W., Brysch, W., Botchway, S.W., Frasch, W., Calabrese, E.J., & Bell, J.D. (2020). SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing. Immun. Ageing, 17(1), 33. DOI: https://doi.org/10.1186/s12979-020-00204-x.
Brugliera, L., Spina, A., Castellazzi, P., Cimino, P., Tettamanti, A., Houdayer, E., …, & Iannaccone, S. (2020). Rehabilitation of COVID-19 patients. J. Rehabil. Med., 52(4), jrm00046. DOI: https://doi.org/10.2340/16501977-2678.
Cesnulevicius, K. (2011). The bioregulatory approach to work-related musculoskeletal disorders: using the multicomponent ultra-low-dose medication Traumeel to target the multiple pathophysiological processes of the disease. Altern. Ther. Health Med., 17(2), S8-S17.
Chua, R.L., Lukassen, S., Trump, S., Hennig, B.P., Wendisch, D., Pott, F., …, & Eils, R. (2020). COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis. Nat. Biotech., 38(8), 970-979. DOI: 10.1038/s41587-020-0602-4. DOI: 10.1038/s41587-020-0602-4.
Ciceri, F., Beretta, L., Scandroglio, A.M., Colombo, S., Landoni, G., Ruggeri, A., …, & Zangrillo, A. (2020). Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. J. Austral. Acad. Critical Care Med., 22(2), 95-97.
St Laurent, G. 3rd, Seilheimer, B., Tackett, M., Zhou, J., Shtokalo, D., Vyatkin, Y., …, & McCaffrey, T.A. (2017). Deep sequencing transcriptome analysis of murine wound healing: effects of a multicomponent, multi-target natural product therapy – Tr14. Front. Mol. Biosci., 4, 57. DOI: 10.3389/fmolb.2017.00057.20.
Laurent, G.St., Toma, I., Tackett, M., Zhou, J., Ri, M., Shtokalo, D., ..., & Mccaffrey T. (2018). AB0080 Differential effects of tr14 versus diclofenac on proresolving lipid mediators revealed by rnaseq. Ann. Rheum. Dis., 77(2), 1237-1238. DOI: https://doi.org/10.1136/annrheumdis-2018-eular.3789.
Fimiani, V., Cavallaro, A., Ainis, O., & Bottari, C. (2000). Immunomodulatory effect of the homoeopathic drug Engystol-N on some activities of isolated human leukocytes and in whole blood. Immunopharmacol. Immunotoxicol., 22(1), 103-115. DOI: 10.3109/ 08923970009016409.
Goldman, A.W., Burmeister, Y., Cesnulevicius, K., Herbert, M., Kane, M., Lescheid, D., …, & Berman, B. (2015). Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patientʼs autoregulatory capacity? Front. Physiol., 6, 225. DOI: https://doi.org/10.3389/fphys.2015.00225.
Kuri-Cervantes, L., Pampena, M.B., Meng, W., Rosenfeld, A.M., Ittner, C.A.G., Weisman, A.R., …, & Betts, M.R. (2020). Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci. Immunol., 5(49), eabd7114. DOI: 10.1126/sciimmunol.abd7114.
Martínez-Sánchez, G., Schwartz, A., & Donna, V.D. (2020). Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants (Basel), 9(5), 389. DOI: https://doi.org/10.3390/antiox9050389.
Mayer, J., Williams, R.J., Oppenheimer, V.A., He, B., Tuckfield, C., Koslowski, E., & Gogal, R.M. Jr. (2016). The immunomodulatory effects of a commercial antiviral homeopathic compound in C57BL/6 mice, pre and post vaccine challenge. Int. Immunopharmacol., 39, 389-396. DOI: https://doi.org/10.1016/j.intimp.2016.08.003.
Wang, M., Baker, J.S., Quan, W., Shen, S., Fekete, G., & Gu, Y. (2020). A preventive role of exercise across the coronavirus 2 (SARS-CoV-2) Pandemic. Front. Physiol., 11, 572718. DOI: https://doi.org/10.3389/fphys.2020.572718.
Müller-Löbnitz, C., & Göthel, D. (2011). Review of the clinical efficacy of the multicomponent combination medication Traumeel and its components. Altern. Ther. Health Med., 17.
Potential use of ozone in SARS-CoV-2/COVID-19. Official Expert Opinion of the International Scientific Committee of Ozone Therapy (ISCO3). ISCO3/EPI/00/04 (March 14, 2020). Approved by ISCO3 on 13/03/2020. Retrieved from: https://aepromo.org/coronavirus/pdfs_doc_ISCO3/Covid19_en.pdf.
Serebrovska, Z.O., Chong, E.Y., Serebrovska, T.V., Tumanovska, L.V., & Xi, L. (2020). Hypoxia, HIF-1α and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol. Sin., 41(12), 1539-1546. DOI: 10.1038/s41401-020-00554-8.
Stebbing, J., Phelan, A., Griffin, I., Tucker, C., Oechsle, O., Smith, D., & Richardson, P. (2020). COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect. Dis., 20(4), 400-402. DOI: https://doi.org/10.1016/S1473-3099(20)30132-8.
Tsyganova, T.N., Kienlein (Balakireva), O.V., Kienlein, K.L., Kapustin, A.V., & Shushardzhan, S.V. (2021). Rationale of the normobaric interval hypoxic training method and the «Detensor» method for long-term-traction of the spinal column combined application in the complex of rehabilitation measures for post-COVID-19 syndrome. Bull. Rehab. Med., 20(2), 11-15. DOI: https://doi.org/10.38025/2078-1962-2021-20-2-11-15.
Wronski, S., Dannenmaier, J., Schild, S., Macke, O., Müller, L., Burmeister, Y., ..., & Müller, M. (2018). Engystol reduces onset of experimental respiratory syncytial virus-induced respiratory inflammation in mice by modulating macrophage phagocytic capacity. PLoS One, 13(4), e0195822. DOI: https://doi.org/10.1371.journal.pone.0195822.
Zhao, H.M., Xie, Y.X., & Wang, C. (2020). Recommendations for respiratory rehabilitation in adults with COVID-19. Chin. Med. J. (Engl), 133(13), 1595-1602. DOI: https://doi.org/10.1097/CM9.0000000000000848.
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