MATHEMATICAL MODEL FOR PREDICTING THE OCCURRENCE OF MODERATE PREECLAMPSIA IN WOMEN AT HIGH RISK OF DEVELOPING LATE GESTOSIS AGAINST THE BACKGROUND OF METABOLIC SYNDROME
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i3.12530Keywords:
late gestosis, vitamin D, inhibin A, neural networksAbstract
In Ukraine, there is a tendency to an increase in the development of complications of pregnancy with late gestosis, therefore, a study using the method of mathematical modeling to predict the occurrence of moderate preeclampsia is advisable and necessary to simplify the verification of this pathology.
The aim – development of a mathematical model to determine the probability and percentage of predicting the occurrence of moderate preeclampsia in women at high risk of developing late gestosis against the background of metabolic syndrome.
Material and Methods. To date, in addition to accurate diagnosis and effective treatment of preeclampsia with obesity, the question has arisen of predicting the development of preeclampsia, using biochemical diagnostic markers. That is, with what probability may moderate preeclampsia occur in women at risk of developing late gestosis against the background of metabolic syndrome. To solve problems of such complexity, neural networks or "artificial intelligence" were used.
Results. It has been mathematically proven that in the presence of proteinuria, which meets the diagnostic criteria for mild preeclampsia, vitamin D deficiency and an increase in inhibin A, the probability of moderate preeclampsia is 89 %.
Conclusions. In patients over 35 years of age, the risk of moderate preeclampsia, given additional prognostic markers, in particular vitamin D and inhibin A, increases the likelihood of developing this complication of pregnancy against the background of metabolic syndrome.
References
Behjat Sasan, S., Zandvakili, F., Soufizadeh, N., & Baybordi, E. (2017). The effects of vitamin d supplement on prevention of recurrence of preeclampsia in pregnant women with a history of preeclampsia. Obstet. Gynecol. Int., 8249264. DOI: 10.1155/2017/8249264.
Magee, L.A., Pels, A., Helewa, M., Rey, E., & von Dadelszen, P. (2014). Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J. Obstet. Gynaecol. Can., 36 (5), 416-438.
Say, L., Chou, D., Gemmill, A., Tunçalp, Ö., Moller, A.B., Daniels, J., ..., & Alkema, L. (2014). Global cause sof maternal death: a WHO systematic analysis. Lancet Glob Health, 2 (6), 323-333.
Javorski, N., Lima, C.A.D., Silva, L.V.C., Crovella, S., & de Azêvedo Silva, J. (2017). Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects. Gene, pii: S0378-1119(17)30933-2. DOI: 10.1016/j.gene.2017.10.087.
Karras, S.N., Wagner, C.L., & Castracane, V.D. (2017). Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism, pii: S0026-0495(17)30275-5. DOI: 10.1016/j.metabol.2017.10.001.
Laird, E., Thurston, S.W., van Wijngaarden, E., Shamlaye, C.F., Myers, G.J., Davidson, P.W., ..., & Strain, J.J. (2017). Maternal Vitamin D status and the relationship with neonatal anthropometric and childhood neurodevelopmental outcomes: results from the seychelles child development nutrition study. Nutrients, 9 (11), pii: E1235. DOI: 10.3390/nu9111235.
Steegers, E.A., von Dadelszen, P., Duvekot, J.J., & Pijnenborg, R. (2010). Pre-eclampsia. Lancet, 376 (9741), 631-644.
Redman, C. (2014). Pre-eclampsia: A complex and variable disease. Pregnancy Hypertens, 4 (3), 241-242.
Ree, P.H., Hahn, W.B., Chang, S.W., Jung, S.H., Kang, J.H., Cha, D.H., ..., & Huh, J.Y. (2011). Early detection of preeclampsia using inhibin a and other second-trimester serum markers. Fetal. Diagn. Ther., 29 (4), 280-286. DOI: 10.1159/000322742.
Shen, Z., Cai, L.Y., Suprapto, I.S., Shenoy, P., & Zhou, X. (2011). Placental and maternal serum inhibin A in patients with preeclampsia and small-for-gestational-age. J. Obstet. Gynaecol. Res., 37 (10), 1290-1296. DOI: 10.1111/j.1447-0756.2010.01513.x.
Lowe, S.A., Bowyer, L., Lust, K., McMahon, L.P., Morton, M.R., North, R.A., ..., & Said, J.M. (2015). SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014. Aust. N Z J. Obstet. Gynaecol., 55 (5), 1-29.
Ventskivska, I.B., Vitovskyi, Ya.M., & Zahorodnia, O.S. (2017). Novi pidkhody do otsinky stanu platsentarnoho krovoobihu pry tyazhkykh formakh preeklampsii [New approaches to the assessment of placental circulation in severe forms of preeclampsia]. Zbirnyk naukovykh prats asotsiatsiii akusher-hinekolohiv Ukrainy – Collection of Sci. Works of the Association of Obstetricians and Gynecologists of Ukraine, 2 (40), 40-44 [in Ukrainian].
Dyndar, O.A. (2016). Retrospektyvnyi analiz perebihu vahitnosti ta polohiv u zhinok iz metabolichnym syndromom [Retrospective analysis of pregnancy and childbirth in women with metabolic syndrome]. Zbirnyk naukovykh prats asotsiatsiii akusher-hinekolohiv Ukrainy – Collection of Sci. Works of the Association of Obstetricians and Gynecologists of Ukraine, 1 (37), 56-61 [in Ukrainian].
Ivanyuta, S.O., Dyndar, O.A., Makarenko, H.I., & Kurochka, V.V. (2017). Metabolichnyy syndrom – pandemiya KHKHI stolittya, nahalna problema akusherstva. Zbirnyk naukovykh prats asotsiatsiii akusher-hinekolohiv Ukrainy – Collection of Sci. Works of the Association of Obstetricians and Gynecologists of Ukraine, 2 (40), 134-138 [in Ukrainian].
Savelyeva, G.M., Krasnopolskiy, V.I., Strizhakov, A.N., Radzinskiy, V.Y., Shalina, R.I., & Kurtser, M.A. (2013). Kakoy klassifikatsii gestozov (preeklampsii) dolzhen priderzhivatsya vrach v povsednevnoy rabote? [To what classification of gestosis (preeclampsia) should adhere a doctor in daily work?]. Zhurnal akusherstva i zhenskikh bolezney – Journal of Obstetrics and Women's Diseases, LXII, 1, 5-9. DOI: https://doi.org/10.17816/JOWD6215-9 [in Russian].
Kaminskyi, V.V., & Zhuk, C.I. (2015). Shliakhy znyzhennia materynskoi smertnosti: ukrainski realii i mizhnarodnyi dosvid [Ways to reduce maternal mortality: Ukrainian realities and international experience]. Zhinochyi likar – Female Doctor, 2, 10-14 [in Ukrainian].
Ostafiichuk, S.O. (2017). Doklinichni markery rozvytku preeklampsii u zhinok z patolohichnym zbilshenniam masy tila pid chas vahitnosti [Preclinical markers of preeclampsia in women with pathological weight gain during pregnancy]. Zbirnyk naukovykh prats asotsiatsiii akusher-hinekolohiv Ukrainy – Collection of Sci. Works of the Association of Obstetricians and Gynecologists of Ukraine, 2 (40), 203-207 [in Ukrainian].
Pyrohova, V.I., & Zhemela, N.I. (2015). Do pytannia roli vitaminu D u zabezpechenni hestatsiinoho protsesu [On the role of vitamin D in ensuring the gestational process]. Zbirnyk naukovykh prats asotsiatsiii akusher-hinekolohiv Ukrainy – Collection of Sci. Works of the Association of Obstetricians and Gynecologists of Ukraine, 2 (36), 189-192 [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
