THE INFLUENCE OF CYTOPROTECTIVE THERAPY ON 2-YEAR SURVIVAL OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND COMORBID PATHOLOGY

Authors

  • V. R. Mykuliak I. Horbachevsky Ternopil National Medical University
  • M. V. Hrebenyk I. Horbachevsky Ternopil National Medical University
  • L. I. Zelenenka I. Horbachevsky Ternopil National Medical University
  • L. V. Zoria I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/1811-2471.2021.v.i3.12525

Keywords:

myocardial infarction, comorbidity, cytoprotective therapy, survival

Abstract

Optimisation of therapeutic strategies for acute myocardial infarction in case of comorbidity is considered to be one of the actual directions of modern medicine. The implementation of this task is possible by the additional to standart treatment administration of cytoprotective therapy (quercetin, L-arginine) in the acute period of myocardial infarction, which is confirmed by analysis of 2-year survival of patients included in the study.

The aim – evaluation of long-term survival of patients with myocardial infarction and comorbid pathology, who were prescribed cytoprotective therapy in acute period additionally to standard protocol treatment.

Material and Methods. 506 patients with acute myocardial infarction admitted to Ternopil cardiology center were examined. Patients were divided into groups according to comorbid pathology. The groups were randomized into subgroups depending on the treatment performed in the acute period of myocardial infarction. The analysis of long-term survival of patients was performed according to the Kaplan-Meier method, the difference was assessed using the log-rank test (c²).

Results. The investigation showed better survival of patients after myocardial infarction who received L-arginine additionally to standard therapy in acute period. Survival rates according to the log rank test differed significantly (c²=2.20; p=0.001) from the group of basic therapy. The cumulative survival rate for patients receiving additional cytoprotective therapy (L-arginine or corvitin) also differed significantly from group receiving only protocol-based standard therapy (c²=14.28; p=0.001).

Conclusions. The results of a 2-year follow-up showed an improvement of long term survival of  patients with myocardial infarction and comorbid pathology in distant postinfarction period who recieved cytoprotective therapy (L-arginine and quercetin) during the acute phase of disease.

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Published

2021-12-01

How to Cite

Mykuliak, V. R., Hrebenyk, M. V., Zelenenka, L. I., & Zoria, L. V. (2021). THE INFLUENCE OF CYTOPROTECTIVE THERAPY ON 2-YEAR SURVIVAL OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND COMORBID PATHOLOGY. Achievements of Clinical and Experimental Medicine, (3), 120–124. https://doi.org/10.11603/1811-2471.2021.v.i3.12525

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Section

Оригінальні дослідження