THE ROLE OF OBESITY AND FEATURES OF ADIPOSE TISSUE TOPOGRAPHY IN THE REALIZATION OF DIABETES MELLITUS TYPE 2
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i4.12480Keywords:
diabetes mellitus type 2, obesity, adipose tissue topography, lipidsAbstract
SUMMARY. Adipose tissue is considered an endocrine organ involved in development of metabolic disorders, and is subdivided into white and brown adipose tissue. Obesity is accompanied by changes in lipid, protein, carbohydrate, and mineral metabolism, as well as the hormonal dysfunction of adipose tissue. It is believed that it is white fat that determines the metabolic disorders and target organ damage. Obesity has the most adverse effect on the course of diabetes mellitus (DM). It has been proved that excessive body weight is a provoking factor in the onset of diabetes mellitus.
The aim – to assess the state of lipid and carbohydrate metabolism in DM type 2 patients regarding their stage of obesity and adipose tissue topography.
Material and Methods. Body mass index (BMI) was assessed according to WHO classification (1997). The distribution of adipose tissue and the ratio of visceral to subcutaneous fat were studied on OMRON BF511 (Japan). Lipid metabolism was assessed by measuring serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol.
Results. It was determined that an increase in BMI is accompanied by an increase in adipose tissue, mainly due to the visceral pool, which content increased by 2.7 times, while subcutaneous adipose tissue increased by 1.8 times.
Conclusions. It was determined that increase in BMI in DM type 2 patients is associated with increase in visceral adipose tissue predominantly and has positive correlation with the stage of obesity. DM type 2 is accompanied by hyperlipidemia which positively correlates with BMI and accumulation of visceral fat.
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