EFFECT OF SMOKING ON ARGINASE AND NITRITE AND NITRATE LEVELS IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY

Authors

  • N. K. Pokrovska Danylo Halytsky Lviv National Medical University
  • A. F. Faynyk Danylo Halytsky Lviv National Medical University
  • Ye. Ya. Sklyarov Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.11603/1811-2471.2021.v.i3.12380

Keywords:

arterial hypertension, obesity, arginase, nitrite and nitrate, comorbid pathology, smoking

Abstract

Arterial hypertension remains one of the most widespread diseases and one of the main factors in the development of cardiovascular events not only in Ukraine but also in the world. Active and passive smoking are among the main risk factors for cardiovascular morbidity and mortality,  and chronic smoking is associated with increased arterial stiffness and decreased elasticity of large and medium-sized arteries.

The aim – to determine the effect of smoking on the level of arginase and nitrates and nitrites (NO2- + NO3-) in patients with arterial hypertension and comorbid obesity.

Material and Methods. We examined 56 patients aged 42–75 years with arterial hypertension and overweight or obesity. 19 (33,9 %) patients smoked. Patients were divided into 2 groups depending on the history of smoking. The following examinations were performed: biochemical analysis of blood, determination of arginase and NO2- + NO3- in plasma.

Results. It was found the negative correlation between the smoking index and SpO2 (p<0.05), which was significantly lower in smokers (p<0.01). Patients with a history of smoking showed a significant increase in arginase concentration (p<0.05), as well as a decrease in NO2- + NO3- (p<0.05). A negative correlation was found between the level of NO2- + NO3- and GFR (p<0.05) in individuals of the 2nd group. It made it possible to consider these molecules as markers of renal parenchymal damage.

Conclusions. Arginase level is higher in patients with arterial hypertension combined with obesity who smoke compared to those without bad habits, while the concentration of NO2- + NO3- is significantly lower. NO2- + NO3- can be considered as markers of renal impairment in patients with comorbid pathology.

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Published

2021-12-01

How to Cite

Pokrovska, N. K., Faynyk, A. F., & Sklyarov, Y. Y. (2021). EFFECT OF SMOKING ON ARGINASE AND NITRITE AND NITRATE LEVELS IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY. Achievements of Clinical and Experimental Medicine, (3), 149–152. https://doi.org/10.11603/1811-2471.2021.v.i3.12380

Issue

No. 3 (2021)

Section

Оригінальні дослідження

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