PREVENTION AND TREATMENT OF TOXIC HEPATITIS AND ENDOGENOUS INTOXICATION IN PATIENTS WITH LYMPHOPROLIFERATIVE DISEASES
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12228Keywords:
hepargin, leukemia, treatment, toxic hepatitis, endogenous intoxicationAbstract
According to the modern epidemiological and statistical studies, recently, in Ukraine, a significant increase in the incidence rate of chronic liver disease was noted. The course is accompanied by the exhaustion of the antioxidant system against to the background of chronic intoxication with metabolic disorders that adversely affect the functional state of the liver.
The aim – is to study the effectiveness of the combined hepatoprotector "Hepargin" as part of complex therapy in patients with hemoblastomas.
Material and Methods. We observed 42 patients with hemoblastomas (6 – with acute lymphoblastic leukemias; 16 – with chronic lymphoid leukemias; 9 – with non-Hodgkin᾽s lymphomas: 7 – with non-Hodgkin᾽s lymphomas from small lymphocytes, and 5 patients – with non-Hodgkin᾽s lymphomas from large granular cells), aged 34–68 years. The average duration of the disease was 4–7 years. All patients underwent ultrasound examination of the abdominal cavity (ultrasound examination) and biochemical parameters of the liver function, namely, alanine aminotransferase, aspartate aminotransferase, bilirubin, alkaline phosphatase, timolol and sulam samples.
Results. In addition to complaints of the underlying disease (which is general weakness, anomalies, heaviness in the lower extremities, dizziness, mischief), the patients were concerned about the severity and sensation of dislocation in the right hypochondrium, nausea. Occasionally, jaundice of the skin and mucous membranes was observed. With ultrasound examination in 17 patients, an increase in liver size was observed. The liver was enlarged at the expense of both particles. In 27 patients, there was an increase in ALT and AST, and in 11 patients, increased bilirubin was observed due to an indirect fraction. The activity of the process mostly corresponded to an average of 58.7 %, and a pronounced 21.3 % degree. In the process of obtaining both mono and polychemotherapy, the activity of the severity of toxic effects on the state of hepatocyte function increased, as indicated by an increase in liver samples. Thus, ALT and AST elevations were observed, as well as an increase in alkaline phosphatase, bilirubin due to an indirect fraction.
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