EVALUATION OF INFLUENCE OF IMMUNE DRUG ON CELL IMMUNITY OF THE PATIENTS AFTER TRAUMATIC BRAIN INJURY ON STAGE OF OUTPATIENT TREATMENT
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12221Keywords:
nucleinatum, traumatic brain injury, cell immunity, outpatient conditionsAbstract
One of the most serious injuries at the present stage is traumatic brain injury (TBI). It often leads to fatal consequences, complicated by traumatic brain disease, which has a chronic and often progressive course. The state of the present immune system is considered to be decisive in the mechanisms of chronicity and damage to the morphology and basic functions of the brain of the victims.
The aim – to study the indicators of cellular immunity in patients with moderate trauma during outpatient observation under the influence of nucleinate.
Material and Methods. The study included 57 patients with moderate traumatic brain injury – moderate brain contusion after surgery for hematoma or depressed fracture of the skull, which were observed on an outpatient basis. Patients were examined for cellular immunity using a test with monoclonal antibodies of classes CD3+, CD4+, CD8+ and CD22 + (NPC "MedBioSpectrum", Moscow, Russia) in a cytotoxic test before discharge and after one month of outpatient supervision.
Results. All patients with TBI who came to the supervision of a neurologist at the outpatient stage, according to the immunological study had signs of secondary immunodeficiency. One month after discharge from the hospital on the background of three weeks of treatment with the addition of nucleinate, there was a significant improvement in all indicators of cellular immunity. The addition of nucleinate to traditional neuroprotective agents at the outpatient stage affected the dynamics of the immunoregulatory index CD4/CD8, which in the main group became higher than in the comparison group by 29.8 % (p <0,05). The values of CD22 + lymphocytes did not change during the observation period.
Conclusions. When adding the drug nucleinate in the outpatient phase of observation of persons with trauma, there was a more significant than in the comparison group, an increase in the total population of T lymphocytes, an increase in CD4 + cells and an increase in CD4 / CD8. Partial recovery of cellular immunity occurred in 31 patients (54.4 %).
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