STATE OF THE BLOOD PLASMA COAGULATION SYSTEM IN NEOPLASTIC INTOXICATION AGAINST ON THE BACKGROUND OF EXPERIMENTAL PHLEBOTHROMBOSIS
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12202Keywords:
experimental chronic neoplastic intoxication, endogenous intoxication, blood coagulation system fibrinogen, blood plasma fibrinolysisAbstract
Deterioration of blood rheological properties greatly affects the formation of thrombi and the development of tissue hypoxia. It is the end-stage fibrinopeptide and thrombinogenesis that are most frequently clinically affected. Examples are DIC, coronary heart disease, myocardial infarction, cerebral stroke, deep vein thrombosis and pulmonary embolism (TELA). The study of phlebothrombosis mechanisms in neoplastic intoxications will allow to prevent complications and improve treatment of many types of pathologies.
The aim – to study the state and morphofunctional changes of the rat blood plasma coagulation system in the modeling of neoplastic intoxication against the background of experimental phlebothrombosis followed by statistical analysis to prevent adverse changes in the hemostasis system.
Material and Methods. The experiment was carried out on 25 sexually mature nonlinear rats. Chronic neoplastic intoxication was modeled by injection of asymmetric 1.2-dimethylhydrazine hydrochloride (DMH) subcutaneously in interscapular region in dose 7/2 mg/kg once per week during 30 weeks according to animal weight – 0.1 ml DMH per 10 g of rat body weight. Deep vein thrombosis of the pelvic limb was modeled by S. Wessler (1959): a combination of venous congestion (vein ligation) and hypercoagulation, due to the introduction of activated coagulation factor (thrombin). Hemostasis testing of blood plasma included determination of PT according to Quick, prothrombin index, activated partial thromboplastin time, fibrinogen A and fibrin monomer complex.
Results. The relationship between phlebothrombosis and neoplastic intoxication and marked changes in blood coagulation systems has been proven.
Conclusions. The performed statistical analysis confirms the activation of the blood coagulation system.
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