RELATIONSHIP BETWEEN INDICES OF BODY COMPOSITION AND FUNCTIONAL CONDITION OF ENDOTHELIAL FUNCTION IN YOUNG WOMEN
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i1.12000Keywords:
endothelial dysfunction, nitric oxide, adipose tissue, adiposityAbstract
Nowadays, the problem of obesity is closely related to endothelial dysfunction. Endothelial dysfunction is characterized by dysfunction of the endothelium in the direction of reduced vasodilation. In turn, endothelial cells play a key role in tissue microcirculation. Neovascularization depends on the synthesis of vascular endothelial growth factor by endothelial cells. In abdominal obesity, there is an increased content of visceral fat, which is accompanied by the production of such pro-inflammatory adipokines as visfatin, tumor necrosis factor-alpha (α-TNF), which reduces the synthesis of nitric oxide by the endothelium.
The aim – to find the relationship between the components of body composition and the functional state of endothelial function in healthy women.
Material and Methods. The study involved 41 healthy female students aged 18–25 years. Measurement of body weight, as well as the determination of such parameters as body mass index (BMI, kg/m2), the percentage of total fat (BF, %), the content of visceral fat (VF, units) and the content of fat-free mass (FFM, %) were performed using scale-analyzer TANITA BC-601 (Japan). The functional state of the endothelium was measured using a test "reactive hyperemia" (RH) with the assessment of endothelium-dependent vasodilation (EDVD). The study was conducted on a rheographic computer device "REOKOM". The results were statistically processed using multifactorial regression and correlation analyzes.
Results. Firstly, multifactorial regression analysis showed that the index of visceral fat, as an independent predictor, had a statistically significant association with the index of endothelium-dependent vasodilation (p<0.0008). Secondly, the index of visceral fat had a statistically significant positive correlation with the index of endothelium-dependent vasodilation (r=0.4211; p<0.006). There was not found a correlation between indices of endothelium-dependent vasodilation and total body fat and fat-free mass (p>0.05).
Conclusions. The increase in visceral fat content is characterized first by increased production of nitric oxide, to improve the vascularization of adipose tissue, and later adipokines will influence on reduction of the synthesis of nitric oxide, which will lead to loss of vascular elasticity, and thus contribute to hypertension.
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