TREATMENT AND PREVENTION OF TOXIC HEPATITIS IN PATIENTS WITH LYMPHOPROLIFERATIVE DISEASES
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i4.11765Keywords:
lymphoma, patients, heparizin, researchAbstract
SUMMARY. The aim – to study the effectiveness of the combined hepatoprotector geparizine as part of complex therapy in patients with hemoblastomas.
Material and Methods. We observed 33 patients with hemoblastomas (3 acute lymphoblastic leukemias, 5 with acute myeloid leukemia, 13 with chronic lymphoid leukemia, and 11 patients with chronic myeloid leukemia) aged 32–67 years. The average duration of the disease was 4–6 years. All patients underwent ultrasound examination of the abdominal cavity (ultrasound examination) and biochemical parameters of the liver function, namely, alanine aminotransferase, aspartate aminotransferase, bilirubin, alkaline phosphatase, timolol and sulam samples.
Results. In addition to complaints of the underlying disease (which is general weakness, anomalies, heaviness in the lower extremities, dizziness), the patients were concerned about the severity and sensation of dislocation in the right hypochondrium, nausea. Occasionally, jaundice of the skin and mucous membranes was observed. With ultrasound examination in 19 patients, an increase in liver size was observed. The liver was enlarged at the expense of both particles. In 11 patients, there was an increase in ALT and AST, and in 11 patients, increased bilirubin was observed due to an indirect fraction. The activity of the process mostly corresponded to an average of 58.7 %, and a pronounced 21.3 % degree. In the process of obtaining both mono and polychemotherapy, the activity of the severity of toxic effects on the state of hepatocyte function increased, as indicated by an increase in liver samples. Thus, ALT and AST elevations were observed, as well as an increase in alkaline phosphatase, bilirubin due to an indirect fraction. Yellowing of the skin and sclera was observed in 5 patients with hemoblastosis.
Conclusions. On the basis of complex treatment with the use of the drug heparizin there was a positive dynamics of the clinical course of the underlying disease, which manifested itself in improved well-being of the patient, general condition, disappearance of heaviness in the right hypochondrium. Analysis of liver function tests under the influence of therapy showed a decrease in the activity of the inflammatory process in hepatocytes what indicated ALT, AST, bilirubin, alkaline phosphatase.
In patients with minimal and moderate activity, the activity of these indicators returned to normal. And in patients with severe activity, these indicators decreased. The positive effect of the drug on protein metabolism was also established, as evidenced by the increase in total serum protein.
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