THE PECULIARITIES OF CARDIOVASCULAR SYSTEM ACTIVITY IN PATIENTS WITH OBSTRUCTIVE APNE-HYPOPNEA SYNDROME AT NIGHT
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i4.11762Keywords:
obstructive sleep apnea-hypopnea syndrome, systemic hemodynamics, cardiac output, total peripheral vascular resistance, circulatory efficiency ratioAbstract
SUMMARY. The article presents the results of studies of the peculiarities of the cardiovascular system activity in patients with obstructive sleep apnea-hypopnea syndrome.
The aim – to evaluate the features of the cardiovascular system activity in patients with obstructive sleep apnea-hypopnea syndrome during sleep.
Material and Methods. The study was conducted in 66 patients diagnosed with obstructive sleep apnea-hypopnea syndrome (OSAHS). The diagnosis of OSAHS was established in patients who during 1 hour of sleep showed more than 5 respiratory stops lasting 10 seconds or more (apnea index – hypopnea, IAH).
Results. It was established that at night during episodes of apnea-hypopnea synchronously with the severity of the pathology, the phenomenon of activation of the cardiovascular system develops, which is manifested by an increase in cardiac output, heart rate and total peripheral vascular resistance. During sleep, the circulatory efficiency ratio (CER) in the patients of the control group decreased by almost 40 %, compared with the data obtained in them during the day. However, in comparison with the control group, at night CER in patients of group 1 was higher by 11.4 %; in patients of group 2 – by 8.0 %; in patients of group 3 – by 25.8 %.
Conclusions. Activation of the cardiovascular system in patients with OSAHS contributes to the formation of hypertension in them, and the growth of total peripheral vascular resistance leads to organ disorders (heart, kidney failure, diabetes, etc.).
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