INFLUENCE OF TOBACCO SMOKING ON GENERAL CLINICAL AND BIOCHEMICAL PARAMETERS OF PATIENTS WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i4.11753Keywords:
anemiaAbstract
SUMMARY. Chronic pancreatitis (CP) in smokers is 2 times more common than in non-smokers, and the risk of developing the disease increases depending on the number of cigarettes smoked.
The aim – to study the effect of smoking (TS) on the main general clinical and biochemical parameters and indicators of endotoxicosis in patients with chronic pancreatitis.
Material and Methods. 64 outpatients without exacerbation were examined: 21 – with isolated CP and 43 – with CP on the background of concomitant TS. The diagnosis was established by the conventional method, the history of smoking was calculated in units of "pack-years" (one pack was 20 cigarettes). The parameters of general clinical and biochemical analysis of blood were determined according to generally accepted methods in the clinic. Evaluation of endogenous intoxication (EI) was performed on the levels of medium weight molecules (MWM1 and MWM2), the level of EI (LEI), as well as the content of circulating immune complexes (CIC) in the serum.
Results. It was found that TS adversely affected the clinical course of chronic pancreatitis without exacerbation due to the presence of manifestations of dyspeptic (14.4 %), pain (7.5 %) and astheno-neurotic (31.1 %) syndromes in more patients-smokers compared with those of non-smokers (p<0.05).
The combination of CP and TS contributed to the deepening of the anemic syndrome (the presence of anemia 88.37 % in the group with TS against 71.42 % in the group without TS; latent anemia – respectively 34.88 % vs 23.80 %; mild 41.86 % against 47.61 %, an average of 11.63 % in the group of smokers in the absence of such in the group of non-smokers) and depletion of the visceral pool of protein in terms of total protein, as well as a greater intensity of inflammation in the pancreatic amylase content in the blood compared to similar parameters in non-smoking patients.
Conclusions. Significantly higher level of endogenous intoxication of patients with chronic pancreatitis was found in the control group (60.71 % – in non-smokers and 102.19 % – in smokers), higher content of MWM1 in the group of healthy smokers compared to that in non-smokers – by 42.46 % vs 30.20 %, as well as a higher level of circulating immune complexes in the group of smokers against that in non-smokers (p<0.05). This proved the complicating effect of smoking on the course of chronic pancreatitis, as well as the depth of general clinical and biochemical laboratory parameters and indicators of endotoxicosis.
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