ULTRASTRUCTURAL STATE OF THE RETINA AND OPTIC NERVE IN THE EXPERIMENTAL NON-INFECTIOUS ANTERIOR AND INTERMEDIATE UVEITIS IN RABBITS WITHOUT TREATMENT AND WITH NEUROPROTECTIVE DRUG
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i3.11586Keywords:
non-infectious uveitis, neurodegeneration, neuroprotectorAbstract
There is no information in the literature on neurodegenerative processes in the retina and optic nerve in anterior and middle uveitis.
The aim – to conduct a comparative ultrastructural study of the optic nerve, the retina and the choroid with non-infectious anterior and intermeidiate uveitis in the experiment.
Material and Methods. The experiment was carried out on 4 rabbits: group 1 – 2 rabbits (without treatment), group 2 – 2 rabbits (got neuroprotective drug). The ultrastructure of the choriocapillaries (CC), retina and optic nerves (ON) were studied after 10 days.
Results. In group 1, ON revealed deep destructive processes in nerve fibers, myelin sheath, in glial cells with destruction by their plasmols and focal intercellular edema. In the choroid and retina, hydropic degeneration of CC endothelial cells and retinal cells, especially PRE and intercellular edema in the fotoreceptor cells area were revealed. In group 2 in the ON, the deformation of the myelin sheaths and the phenomena of edema in the axoplasm are found to a lesser extent and in a smaller amount of nerve fibers. In the axoplasm of most nerve fibers, mitochondria and other organelles had normal ultrastructure. Small caliber nerve fibers were found to be the most intact. In the CC layer, endothelial cells with signs of compensation and recovery processes prevailed. Along with this, a part of the CC endothelial cells remained in a state of edema.
Conclusions. Anterior and middle non-infectious uveitis, modeled with horse serum, in the early stages causes neurodegenerative changes in the retina and ON, and under using a neuroprotective drug (for 10 days), the phenomena of neurodegeneration are less pronounced.
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