PECULIARITIES OF THE CONDITION OF FUNCTIONAL INSUFFICIENCY OF THE PANCREAS IN THE COMORBIDITY OF CHRONIC PANCREATITIS AND TYPE 2 DIABETES MELLITUS ON THE BACKGROUND OF PRIMARY OSTEOARTHRITIS

Abstract

SUMMARY. Recent studies have shown a significant effect of pancreatic conditions on the course of comorbid pathology in patients with primary osteoarthritis.

The aim – to study the state of functional capacity of the pancreas in patients with comorbid chronic pancreatitis and type 2 diabetes mellitus on the background of primary osteoarthritis.

Material and Methods. 117 patients with CP on the background of primary OA with concomitant diabetes mellitus and without it were studied. The main group consisted of 92 outpatients with CP on the background of primary OA in combination with diabetes mellitus in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP on the background of primary OA, and the control group – 30 healthy individuals.

Results and Discussion. With the comorbidity of CP and diabetes mellitus on the background of primary OA, the excretory insufficiency of the pancreas was significantly more severe than in the group of patients with isolated CP, the content of fecal α-elastase – respectively (110.35±1.81) μg/g and (159.56±4.15) μg/g, which corresponded to the average and mild degrees of excretory insufficiency of the pancreas, respectively, and the score of the coprogram – respectively (5.60±0.10) and (3.89±0.16) points (p<0,05).

Conclusions. In the combined course of CP and diabetes mellitus on the background of OA, the correlation between fecal α-elastase-1 and glycosylated hemoglobin was statistically significantly stronger than in the group of patients with isolated CP, indicating a mutual burden of CP and diabetes mellitus.