EFFICIENCY OF VITAMIN THERAPY AND AMINO ACID DRUG USE IN COMPLEX TREATMENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT ANEMIA OF CHRONIC DISEASES IN PATIENTS WITH PULMONARY TB HISTORY
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i2.11323Keywords:
chronic obstructive pulmonary disease, history of pulmonary tuberculosis, anemia of chronic diseases, vitamin therapy, amino acid drugAbstract
The aim of the study – to learn the efficiency of vitamin therapy and amino acid drug use in treatment of chronic obstructive pulmonary diseases (COPD) in patients with anemia of chronic diseases (ACD) and a history of pulmonary tuberculosis (TB).
Material and Methods. 95 COPD patients with ACD and a history of TB were examined according to the clinical protocols with iron metabolism study, anxiety and depression index detection, and who additionally to the standard COPD treatment received group B vitamins with or without amino acid (ademetionine) drug.
Results. In COPD patients with ACD and a history of TB a prescription of group B vitamins with or without amino acid (ademetionine) drug additionally to the standard COPD treatment lead to significant improvement not only of clinical presentation and pulmonary function tests but of red blood characteristics, decrease in inflammation intensity and depression index as well, predominantly in the group of patients who took a combination of group B vitamins and ademetionine.
Conclusions. It is advisable to prescribe vitamin therapy and amino acid drug in addition to standard therapy for the correction of red blood counts, the normalization of systemic inflammation and the depression index for patients with a history of COPD and TB.
References
Feshhenko, Yu.I., Gavrysyuk, V.K., Dzyublyk, O.Ya., Mostovoy, Yu.M., Pertseva, T.O., Polyanska, M.O., Yachnyk, A.I., & Yashyna, L.O. (2019). Adaptovana klinichna nastanova: khronichne obstruktyvne zakhvoriuvannia lehen (chastyna 1) [Adapted clinical guidelines: chronic obstructive pulmonary disease (part 1)]. Ukrainskyi pulmonolohichnyi zhurnal – Ukrainian Pulmonology Journal, 2, 5-18 [in Ukrainian].
Zakaria, M.W., & Moussa, H.A. (2015). Chronic obstructive pulmonary disease in treated pulmonary tuberculous patients. Egyptian Journal of Bronchology, 9, 10-13. DOI: https://doi.org/10.4103/1687-8426.153519
Gil-Santana, L., Cruz, L.A.B., Arriaga, M.B., Miranda, F.C., Fukutani, K.F., Silveira-Mattos, P.S., ..., & Andrade В.В. (2019) Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy. Sci. Rep., 9, 1381. DOI: 10.1038/s41598-018-37860-5. DOI: https://doi.org/10.1038/s41598-018-37860-5
Padberg, І., Schneider, А., Lee Rohmann, J., Kelley, S.W., Grittner, U., & Siegerink, В. (2020). Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing. Respir. Res., 21, 40. DOI: 10.1186/s12931-020-1305-6 DOI: https://doi.org/10.1186/s12931-020-1305-6
Xiong, W., Xu, М., Pudasaini, В., Guo, Х., & Liu, J. (2018) The influence of anemia on one-year exacerbation rate of patients with COPD-PH. BMC Pulmonary Medicine, 18, 143. DOI: 10.1186/s12890-018-0693-6 DOI: https://doi.org/10.1186/s12890-018-0693-6
Yohannes, A. & Alexopoulos, G. (2014) Depression and anxiety in patients with COPD. European Respiratory Review: An Official Journal of the European Respiratory Society, 23, 345-349. DOI: 10.1183/09059180.00007813. DOI: https://doi.org/10.1183/09059180.00007813
Zhovanyk, N.V., Tovt-Korshynska, M.I., & Rostoka-Reznikova, M.V. (2020). Osoblyvosti diahnostyky ta likuvannia khronichnoho obstruktyvnoho zakhvoriuvannia lehen iz suputnoiu anemiieiu khronichnykh zakhvoriuvan u osib, shcho perenesly tuberkuloz lehen [Features of diagnosis and treatment of chronic obstructive pulmonary disease with concomitant anemia of chronic diseases in persons who have suffered from pulmonary tuberculosis]. Eurasisn Scientific Congress. Abstracts of the 3rd International Scientific and Practical Conference. Barca Academy Publishing. Barcelona. Spain [in Ukrainian].
Mikkelsen, K., Stojanovska, L., & Apostolopoulos, V. (2016). The effects of vitamin B in depression. Current Medicinal Chemistry, 23. DOI: 10.2174/0929867323666160920110810. DOI: https://doi.org/10.2174/0929867323666160920110810
Galizia, І., Oldani, L., Macritchie, K., Amari, E., Dougall, D., Jones, T.N. ..., & Young, A.H. (2014). Sadenosyl methionine (SAMe) for depression in adults. Cochrane Database of Systematic Reviews, 9, CD011286. DOI: 10.1002/14651858.CD011286. DOI: https://doi.org/10.1002/14651858.CD011286
Folsom, A.R., Desvarieux, М., Nieto, F.J., Boland, L.L., Ballantyne, C.M., & Chambless, L.E. (2003). B vitamin status and inflammatory markers. Atherosclerosis, 169 (1), 169-174. DOI: https://doi.org/10.1016/S0021-9150(03)00161-8
(2013). Pro zatverdzhennia unifikovanoho klinichnoho protokolu pervynnoi, vtorynnoi (spetsializovanoi) ta tretynnoi (vysokospetsializovanoi) medychnoi dopomohy ta medychnoi reabilitatsii khronichnoho obstruktyvnoho zakhoriuvannia lehen: nakazu MOZ Ukrainy № 555 vid 27.06.2013 r. [On approval of the unified clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical care and medical rehabilitation of chronic obstructive pulmonary disease: order of the Ministry of Health of Ukraine No. 555 of 27.06.2013]. Ministerstvo okhorony zdorovia Ukrainy – Ministry of Health of Ukraine [in Ukrainian].
(2015). Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) medychnoi dopomohy. Zalizodefitsytna anemiia. Nakaz MOZ Ukrainy № 709 vid 02 lystopada 2015 r. [Unified clinical protocol of primary, secondary (specialized) medical care. Iron deficiency anemia. Order of the Ministry of Health of Ukraine No. 709 of November 2, 2015]. Ministerstvo okhorony zdorovia Ukrainy – Ministry of Health of Ukraine [in Ukrainian].
Beck Depression Inventory-II [online resource]. Retrieved from: https://www.kdheks.gov/c-f/integration_toolkits/Beck_Depression_ Inventory_II.pdf
