ADIPOKINES AND HYPERTENSION DISEASE: CLINICAL AND THERAPEUTIC VALUE
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i2.11301Keywords:
adipokines, hypertension, leptin, resistin, omentin, visfatinAbstract
The review presents current data from the literature on the physiological and pathophysiological role of adipose tissue hormones (leptin, resistin, omentin, visfatin).
The aim – to analyze publications that reflect already known aspects of the biological action and regulation of adipokines, and demonstrate the results of recent studies, as well as show trends and development prospects in the study of the clinical and pathogenetic significance of adipose tissue hormones.
Results. The main mechanism of the negative impact of adipose tissue on the cardiovascular system is its hormonal activity. There is a positive correlation between blood pressure figures and plasma adipokines levels. The article discusses in detail the role of adipokines in the development of hypertension, because they are directly involved in the mechanisms of blood pressure, atherogenesis, regulation of oxidative stress, blood clotting and the development of non-infectious inflammation. The review presents the results of foreign studies on the relationship between hypertension, lipid metabolism and adipokine imbalance.
Conclusions. Disorders of adipokines secretion and function may be a leading factor in the development of hypertension and cardiovascular disease. These peptides have different effects on the body and in violation of the interaction contribute to the development of socially significant diseases such as myocardial infarction, hypertension, stroke, atherosclerosis, metabolic syndrome.
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