INCREASING EFFICIENCY OF COMPLEX TREATMENT OF PATIENTS WITH LYME BORRELIOSIS USING STEVIA REBAUDIANA
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11087Keywords:
Lyme borreliosis, doxyxycline hydrochloride, Stevia rebaudiana, treatmentAbstract
The aim – improvement of the complex treatment of patients with Lyme borreliosis, using of combined application of doxycycline hydrochloride and infusion of Stevia rebaudiana leaves.
Material and methods. The tested group consisted of 113 patients with erythematous form of Lyme borreliosis; men – 49 (43.4 %), women – 64 (56.6 %). The average age of the examined persons was (42.65 ± 13.91) years. Two schemes of complex treatment of patients were tested. Patients of group 1 (53) received doxyxycline hydrochloride 200 mg per day (in 2 doses of 100 mg) for 21 days, carsil and hylak; patients of group 2 (60) took the first regimen for 14 days, and then only infusion from the leaves of Stevia rebaudiana, 1 glass twice a day, for 14 days.
Results. A significant decrease of the severity of the disease was noted on the 30-th day after treatment in patients, who received doxyxycline hydrochloride together with infusion from the leaves of Stevia rebaudiana in a complex treatment, compared with patients of another group.
Complex therapy of patients with Lyme borreliosis, using infusion from the leaves of Stevia rebaudiana, causes a decrease of the content of pro-inflammatory IL-18 and increase of anti-inflammatory IL-10 in blood serum.
Conclusions. The complex treatment of patients with erythematous form of Lyme borreliosis, using an infusion from the leaves of Stevia rebaudiana contributes to a significantly faster disappearance of the clinical manifestations of the disease, reduction duration of the doxyxycline hydrochloride, and reduces the bedside effects of this drug. The use of doxyxycline hydrochloride in combination with infusion from the leaves of Stevia rebaudiana in treatment of the patients with erythematous form of Lyme borreliosis contributes to a significantly faster provides an early anti-inflammatory response, the formation of cellular and humoral immunity, which contributes to the alimination of Borrelia and patient's recovery.
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