EFFECTIVENESS OF COMBINED SEQUENTIAL THERAPY OF ACTINIC KERATOSIS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11083Keywords:
actinic keratosis (AK), IPL, cryodestruction, combination therapyAbstract
The aim – to evaluate the effectiveness of the use of combination sequential therapy of actinic keratosis (AK), comparing it with the results of therapeutic effectiveness of monotherapy (liquid nitrogen cryodestruction).
Material and Methods. A three-stage combination therapy algorithm was developed to sequentially remove areas of atypical keratinocyte proliferates, to reduce vascularization in existing AK lesions, and in potentially possible new ones on adjacent skin areas, as well as to improve skin condition.
There were 90 patients with AK under observation. All patients were randomized into two groups. Patients of group 1 (58 persons) received the combination therapy according to the developed technique, patients of group 2 (32 persons) received only liquid nitrogen cryodestruction (monotherapy).
Results and Conclusions. According to the analysis of complaints and clinical data of patients before and after the treatment, it was proven that combination therapy provides the best clinical and cosmetic effects comparing with monotherapy. High therapeutic efficacy, good tolerability, minimally invasive procedures, accessibility, ease of use make it possible to recommend this technique for the treatment of AK patients in Ukraine.
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