A MODERN LOOK AT THE DIAGNOSTICS OF HYPERPLASTIC PROCESSES OF THE ENDOMETRIUM

(LITERATURE REVIEW)

Authors

  • T. V. Vereshchagina I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/1811-2471.2020.v.i1.11063

Keywords:

endometrial hyperplastic processes, the role of the infectious factor, viral etiology

Abstract

The aim of the work – to analyze the perspective and possibilities of diagnostics of endometrial hyperplastic processes (EHP) in women of childbearing age using domestic and foreign literature.

Material and Methods. The study used bibliosystematic and analytical methods. During the study, 37 sources of contemporary and foreign literature were analyzed for methods and novelty of diagnosis of EHP.

Results. Endometrial pathology is diagnosed during a self-referral to an ultrasound physician, while subsequent pathohistological examination often reveals the presence of endometrial hyperplasia. Treatment, which is aimed at inhibiting proliferative processes in the endometrium, is currently prescribed by the doctor, taking into account his own experience, the material capabilities of the patient, the possible side effects. But it is difficult to predict how effective therapeutic tactics will be. Some researchers report that after a course of hormone therapy, 45 % of process recurrences are observed in the treatment of EHP. The analysis of the literature review indicates the urgency of the problem of urogenital infection as an etiological factor, which requires further more in-depth study of its prevalence, etiology and pathogenesis, as well as features of clinical manifestations and course.

Conclusions. A further in-depth study of the prevalence and spectrum of clinical manifestations of genital viral infection, as well as the pathogenetic mechanisms of long-term persistence of HPV in the body, will help to develop improved combined approaches to treating EHP, including new ones.

References

Zaporozhan, V.M. (Ed.). (2014). Akusherstvo ta hinekolohiia: u 4 t. : natsionalnyi pidruchnyk. T. 3. Neoperatyvna hinekolohiia [Obstetrics and Gynecology: In 4 volumes: national textbook. Vol. 3. Non-surgical gynecology]. Kyiv: VSV “Medytsyna” [in Ukrainian].

Baziuta, L.Z. (2015). Diahnostyka porushen klitynnoho imunitetu u zhinok iz hiperplaziieiu endometriia [Diagnosis of cellular immunity disorders in women with endometrial hyperplasia]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Bulletin, 19, 3 (75), 7-10 [in Ukrainian].

Vdovchenko, Yu.P., Holyanovskyi, O.V., & Lopushan, I.V. (2012). Leiomioma matky: (chastyna 1) [Uterine leiomyoma: (part 1)]. Mystetstvo likuvannia – The Art of Treatment, 2-3, (88-89), 47-54 [in Ukrainian].

Vovk, Y.B., Borysyuk, O.Yu., & Horban, N.E. (2016). Sovremennyye predstavleniya o giperplazii endometriya [Modern ideas about endometrial hyperplasia]. Hinekolohiya, Akusherstvo, Reproduktolohiia – Genecology, Obstetrics, Reproductology, 2 (22), 70-74 [in Russian].

Dobrokhotova, Yu.E., Venediktova, M.G., & Saprykina, L.V. (2010). Endokhirurgicheskie metody lecheniya predrakovykh sostoyaniy endometriya [Endosurgical methods of treatment of precancerous conditions of the endometrium]. Lechebnoe delo – Medical Business, 2, 66-69 [in Russian].

Kipich, N.V. (2011). Znachimost molekulyarno-geneticheskikh i immunologicheskikh faktorov v patogeneze i taktike vedeniya bolnykh giperplasticheskimi protsessami endometriya [The significance of molecular genetic and immunological factors in the pathogenesis and tactics of management of patients with endometrial hyperplastic processes]. Candidate’s thesis. Saint-Petersburg [in Russian].

Litvinova, N.A., Grishin, I.I., Aliyeva, A.A., Filatova, L.A., Demura, T.A., Kapranov, S.A., & Dobrokhotova, Yu.E. (2009). Kliniko-morfologicheskoe sostoyanie endometriya v otdalennom postembolizatsionnom periode u bolnykh s sochetannoy dobrokachestvennoy patologiey endometriya i miometriya [Clinical and morphological state of the endometrium in the remote postembolization period in patients with combined benign pathology of the endometrium and myometrium]. Lechebnoe delo – Medical Matter, 4, 47-51 [in Russian].

Kogan, E.A., Nizyaeva, N.V. & Demura, T.A. (2010). Morfologicheskie i immunogistokhimicheskie osobennosti ochagov adenomioza pri sochetanii s adenokartsinomoy endometriya [Morphological and immunohistochemical features of foci of adenomyosis in combination with endometrial adenocarcinoma]. Arkhiv patol. – Archive of Pathol., 4, 7-12 [in Russian].

Kuznetsova, I.V. (2009). Giperplasticheskie protsessy endometriya [Hyperplastic processes of the endometrium]. [in Russian].

Ozolinya, L.A., Lapina, I.A., Boldina, B.B. & Lutsenko, N.N. (2011). Lechenie patsientok, stradayushchikh giperplaziey endometriya v sochetanii s miomoy matki [Treatment of patients suffering from endometrial hyperplasia in combination with uterine myoma]. Lechebnoe delo – Medical Matter, 2, 34-39 [in Russian].

Hromova, A.M., Afanaseva, O.Ye., Martynenko, V.B., & Hromova, O.L. (2013). Maloinvazyvna khirurhiia v diahnostytsi ta likuvanni patolohii endometriia [Minimally invasive surgery in the diagnosis and treatment of endometrial pathology]. Svit medytsyny ta biolohii – World of Medicine and Biology, 3 (39), 92-94 [in Ukrainian].

Manukhin, I.B. (2010). Nereshennye problemy terapii sochetannykh dobrokachestvennykh novoobrazovaniy gormonalno zavisimykh organov (obzor literatury) [Unresolved problems in the treatment of counted benign neoplasms of hormone-dependent organs (literature review)]. Russkiy meditsinskiy zhurnal – Russian Medical Journal, 18 (4), 176-179 [in Russian].

Novikova, V.A. (2010). Osobennosti kontratseptsii pri gormonoterapii dobrokachestvennykh giperplaziy v zhenskoy reproduktivnoy sisteme [Features of contraception during hormone therapy of benign hyperplasia in the female reproductive system]. Zdorovye zhenshchiny – Women’s Health, 10, 180-183 [in Russian].

Podolskyi, V.V. (2016). Korektsiia porushen vegetatyvnoho homeostazu v zhinok fertylnoho viku zi zminamy reproduktyvnoho zdorovia [Correction of disorders of vegetative homeostasis in women of fertile age with changes in reproductive health]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Actual Problems of Pediatrics, Obstetrics and Gynecology, 1, 112-119 [in Ukrainian].

Potapov, V.O., Donska, Yu.V., & Medvediev, M.V. (2014). Suchasni pidkhody do likuvannia hiperplazii endometriia u zhinok z leiomiomoiu matky [Modern approaches to the treatment of endometrial hyperplasia in women with uterine leiomyoma]. Medychni perspektyvy – Medical Perspectives, XIX, (3), 23-29 [in Ukrainian].

Saprykina, L.V., Dobrokhotova, Yu.E., & Litvinova, N.A. (2011). Giperplasticheskie protsessy endometriya: voprosy etiopatogeneza, kliniki, diagnostiki, lecheniya [Hyperplastic processes of endometrium: issues of etiopathogenesis, clinics, diagnostics, treatment]. Lechebnoe delo – Medical Business, 1, 4-8 [in Russian].

Slyusareva, O.A. (2013). Dokazano ili net? Sovremennye predstavleniya o lechenii giperplazii endometriya (obzor literatury) [Proved or not? Contemporary notions on the treatment of endometrial hyperplasia (literature review)]. Vestnik novykh meditsinskikh tekhnologiy – Bulletin of New Medical Technologies, XX, (2), 339-342 [in Russian].

Zaporozhan, V.N., Tatarchuk, T.F., Dubinina, V.G., & Kosey, N.V. (2012). Sovremennaya diagnostika i lechenie giperplasticheskikh protsesov endometriya [Modern diagnostics and treatment of endometrial hyperplastic processes]. Reproduktivnaya endokrinologiya – Reproductive Endocrinology, 1 (3), 5-12 [in Russian].

Trailina, O.S. (2010). Giperplasticheskie protsessy endometriya. Sostoyanie problemy na sovremennom etape [Hyperplastic processes of the endometrium. State of the problem at the present stage]. Aktualnі pytannia medytsyny і farmatsіi – Current Issues of Medicine and Pharmacy. Abstracts. (pp. 32-33). Zaporіzhzhia [in Ukrainian].

Fedorych, P.V., Stepanenko, R.L., & Fedorych, L.Ya. (2008). Likuvannia papilomavirusnoi henitalnoi infektsii preparatom “Panavir” [Treatment of papillomavirus genital infection by Panavir]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii – Ukrainian Journal of Dermatology, Venereology, Cosmetology, 4 (31), 93-96 [in Ukrainian].

Fen, I., Sidorovaa, I.S. & Stanoevich, I.V. (2012). Sochetanie giperplasticheskikh protsessov endometriya s khronicheskim endometritom [Combination of endometrial hyperplastic processes with chronic endometritis]. Hinekolohiia, Akusherstvo, Reproduktolohiia – Genecology, Obstetrics, Reproductology, 6 (1), 31-33 [in Russian].

Chernukha, G.E. (2013). Ekspresiya genov, reguliruyuyushchikh apoptoz, pri razlichnykh tipakh giperplazii endometriya i endometrioidnoy kartsinome [Expression of apoptosis-regulating genes in various types of endometrial hyperplasia and endometrioid carcinoma]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 1, 63-69 [in Russian].

Lacey, J.V.Jr., Sherman, M.E., Rush, B.B., Ronnett, B.M., Ioffe, O.B., Duggan, M.A., ..., & Langholz, B. (2010). Absolute risk of endometrial carcinoma during 20-year follow-up among women with endometrial hyperplasia. J. Clin. Oncol., 28 (5), 788-792. DOI: https://doi.org/10.1200/JCO.2009.24.1315

Verstraelen, H., Vilchez-Vargas, R., Desimpel, F., Jauregui, R., Vankeirsbilck, N., Weyers, S., ..., & Van De Wiele, T. (2016). Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J., 19, 4, e1602. DOI: https://doi.org/10.7717/peerj.1602

Danussevich, I.N. (2013). Risk factors for the development of chronic endometritis in women with reproductive disorders. Bulletin of ESSC SB RAMS, 4 (92).

Daya, D. (2014). Endometrial hyperplasia and carcinoma with superimposed secretory changes: a double whammy. Int. J. Gynecol. Pathol., 33(2), 105-106. DOI: https://doi.org/10.1097/PGP.0000000000000115

Acmaz, G., Aksoy, H., Albayrak, E., Baser, M., Ozyurt, S., Aksoy, U., & Unal, D. (2014). Evaluation of endometrial precancerous lesions in postmenopausal obese women-a high risk group? Asian. Pac. J. Cancer Prev., 15 (1), 195-198. DOI: https://doi.org/10.7314/APJCP.2014.15.1.195

Funkhouser, L.J., & Bordenstein, S.R. (2013). Mom knows best: the universality of maternal microbial transmission. PLoS Biol., 11 (8), e1001631. DOI: https://doi.org/10.1371/journal.pbio.1001631

Moore, S.G., Ericsson, A.C., Poock, S.E., Melendez, P., & Lucy, M.C. (2017). Hot topic: 16s rRNA gene sequencing reveals the microbiome of the virgin and pregnant bovine uterus. Journal of Dairy Science, 100 (6), 4953-4960. DOI: https://doi.org/10.3168/jds.2017-12592

Stout, M.J., Conlon, B., Landeau, M., Lee, I., Bower, C., Zhao, Q., ..., & Mysorekar, I.U. (2013). Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations. Am. J. Obstet. Gynecol., 208 (226), 221-227. DOI: https://doi.org/10.1016/j.ajog.2013.01.018

Trimble, C.L., Method, M., Leitao, M., Lu, K., Ioffe, O., Hampton, M., ..., & Mutter, G.L. (2012). Management of endometrial precancers. Obstet. Gynecol., 120 (5), 1160-1175. DOI: https://doi.org/10.1097/AOG.0b013e31826bb121

Mitchell, C.M., Haick, A., Nkwopara, E., Garcia, R., Rendi, M., Agnew, K., ..., & Eschenbach, D. (2015). Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am. J. Obstet. Gynecol., 212, 611-619. DOI: https://doi.org/10.1016/j.ajog.2014.11.043

Horban, N.Ye., Vovk, I.B., Lysiana, T.O., Ponomariova, I.H., & Zhulkevych, I.V. (2019). Peculiarities of uterine cavity biocenosis in patients with different. Journal of Medicine and Life, 12, 3, 266-270.

Cicinelli, E., Matteo, M., Tinelli, R., Lepera, A., Alfonso, R., Indraccolo, U., Marrocchella, S., ..., & Resta, L. (2015). Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Human Reproduction, 30, 323-330. DOI: https://doi.org/10.1093/humrep/deu292

Petrov, Iu.A. (2012). Chronic endometritis in reproductive age: etiology, pathogenesis, diagnosis, treatment and prevention. Extended abstract of Doctor’s thesis.

Howlader, N., Noone, A.M., Krapcho, M., Garshell, J., Neyman, N., Altekruse, S.F., & Cronin, K.A. (Eds). (2012). SEER Cancer Statistics Review. National Cancer Institute, 1975-2010.

Giuntoli, R.L.2nd, Gerardi, M.A., Yemelyanova, A.V., Ueda, S.M., Fleury, A.C., Diaz-Montes, T.P., & Bristow, R.E. (2012). Stage I noninvasive and minimally invasive uterine serous carcinoma: comprehensive staging associated with improved survival. Int. J. Gynecol. Cancer., 22 (2), 273-279. DOI: https://doi.org/10.1097/IGC.0b013e318238df4d

Published

2020-03-31

How to Cite

Vereshchagina, T. V. (2020). A MODERN LOOK AT THE DIAGNOSTICS OF HYPERPLASTIC PROCESSES OF THE ENDOMETRIUM: (LITERATURE REVIEW). Achievements of Clinical and Experimental Medicine, (1), 6–13. https://doi.org/10.11603/1811-2471.2020.v.i1.11063

Issue

Section

Огляд літератури