FEATURES OF CLINICAL COURSE OF RHEUMATOID ARTHRITIS ASSOCIATED WITH BORRELIA BURGDORFERI
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10810Keywords:
rheumatoid arthritis, Borrelia burgdorferi, diagnostics, Baker’s cysts, Lyme arthritisAbstract
The study of infectious arthritis in rheumatology practice is becoming more and more relevant every year, since today the arthritis associated with Borrelia burgdorferi (B. burgdorferi) is a serious medical, biological and medico-social problem due to the tendency to develop chronic diseases of apparatus that leads to adverse effects – prolonged disability and disability of people of all ages and genders.
The aim – establish clinical features of RA associated with B.burgdorferi.
Material and Methods. 63 patients in the age between 19 and 73 participated in our study. They were examined in the rheumatology department of Ternopil University Hospital. There were 19 (30.15 %) men and 44 (69.85 %) women. Patients were divided into 2 groups: 34 (group 1) – patients with RA associated with B. burgdorferi, 29 (group 2) – isolated RA. The diagnosis of RA has been verified according to the classification criteria (ACR/EULAR 2010). A visual analogue pain scale (VAS) was used to analyze the pain intensity, a DAS 28 activity scale was used to characterize RA activity.
Results. The study found that the presence of B. burgdorferi in patients with RA was associated with faster development of the disease and a high degree of activity of the inflammatory process. Among those examined with laboratory-confirmed B. burgdorferi, there was a great number of patients positive in аnti-CCP and RF. Among the group examined for RA with B. burgdorferi showed a high percentage of patients with Baker's cysts and structural changes on the radiograph. The rates of pain syndrome by VAS were significantly higher in patients with RA associated with B. burgdorferi (p<0.05).
Conclusions. It was demonstrated that the presence of B. burgdorferi in the group of patients promotes the progression of arthritis, causes a more severe clinical picture of the disease and is a predictor of the development of a more pronounced degree of joint destruction.
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