MORPHOLOGICAL STUDY OF JOINT TISSUES IN RATS WITH EXPERIMENTAL ARTHRITIS UNDER THE INFLUENCE OF PHYTOCOMPOSITION BASED ON ARTHRITAN DRUG
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10808Keywords:
Arthritan, chondroprotective activity, morphostructure of the cartilage, systemic steroid arthritisAbstract
An urgent problem of the medical and pharmaceutical industry today is the production of high-quality herbal drugs to meet the needs of the population of our country.
The aim – to study chondroprotective properties of phytocomposition based on the drug Arthritan under the conditions of evaluation of the morphostructure of the cartilage tissue of rats with experimental arthritis.
Material and Methods. The study of chondroprotective properties of the investigated phytocomposition based on the drug Arthritan was conducted under the conditions of systemic steroid arthritis modeling in rats. Animals received phytocomposition at a conditional therapeutic dose of 0.1 ml/kg. The effectiveness of the phytocomposition was evaluated by the results of the rats articular cartilage morphostructure study.
Results and Discussion. During the histological study of the rats joints with experimental arthritis under the influence of the studied phytocomposition at a dose of 0.1 ml/kg, a cytological picture with mild pathological manifestations was observed. The use of the studied phytocomposition in the treatment of animals with experimental arthritis leads to the normalization of the morphological structure of articular tissues, with the presence of mild disorders in the structures of the cartilage and capsule of the joint. As a result of this, the cartilage surface becomes more even, with no signs of fibrillation, the state of cytoarchitectonics normalizes, the color of the matrix becomes more uniform, with minimal manifestations of destruction, and dystrophic changes in chondrocytes. By the level of this activity, the phytocomposition is not inferior to the reference drug Arthron Flex, a well-known chondroprotective agent that is widely used in clinical practice for the treatment of patients with osteoarthritis.
Conclusions. On the model of systemic steroid arthritis in rats, a positive therapeutic effect of the studied phytocomposition was established along with the well-known chondroprotector Arthron Flex, which is confirmed by the improvement of the articular tissues ultrastructure.
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