PATHOMORPHOLOGICAL FEATURES OF THE LIPOPOLYSACCHARIDE PERIODONTITIS DEVELOPMENT ASSOCIATED WITH CHRONIC ATROPHIC GASTRITIS
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10790Keywords:
periodontitis, atrophic gastritis, morphological changesAbstract
Inflammatory diseases of periodontal tissues are one of the most important problems in dentistry. There is a strong association between periodontal pathology and inflammatory diseases of the stomach.
The aim of the work was to study the pathomorphological changes in the periodontal tissues of rats with generalized lipopolysaccharide periodontitis associated with chronic atrophic gastritis.
Material and Methods. In rats, generalized lipopolysaccharide periodontitis was modeled by introducing 40 microliters (1 mg/ml) of lipopolysaccharide into the gum tissue for 2 weeks. Atrophic gastritis was caused by intragastric administration for 6 weeks with 2 % sodium salicylate and 20 mM sodium deoxycholate. Histological preparations of the upper jaw fragments were stained with hematoxylin and eosin.
Results. In generalized lipopolysaccharide periodontitis the reorganization of all structural components of the gum tissues occurs. It is manifested by changes in the epithelium of the mucous membrane of the gums, an increase in the stratum corneum, a decrease in the spinous layer, an expansion of the intercellular spaces, an increase in lymphocytic infiltration, swelling of the connective tissue, expansion of the veins and hemocapillaries, thickening of the walls of arteries, swelling of the amorphous substance of the connective tissue and damage to its fibrous structures. In periodontitis on the background of gastritis, all structural changes are manifested to a greater extent than in animals with periodontitis without somatic pathology.
Conclusion. Concomitant chronic atrophic gastritis significantly worsens the pathomorphological picture of periodontitis induced in animals by endotoxin of gram-negative microflora lipopolysaccharide.
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