CHARACTERISTICS OF THE INTESTINAL MICROFLORA COMPOSITION IN PATIENTS WITH DIARRHEA AND POSSIBLE CLOSTRIDIUM DIFFICILE INFECTION
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10473Keywords:
intestinal dysbacteriosis, pseudomembranous colitis, Clostridium difficile infection, bacteriological diagnosisAbstract
The qualitative and quantitative composition of the microflora in the gastrointestinal tract may vary depending on various factors. However, inflammatory processes that will foster the development of such an endogenous infection as Clostridium difficile infection (CDI) may take place in the mucous membrane.
The aim – to study the nature of changes in the qualitative and quantitative composition of the intestinal microflora in patients with possible CDI.
Materials and Methods. The bacteriological method has been used to examine samples of biotic material (faeces) received from 73 patients with clinical manifestations of CDI. The given samples have been subjected to dysbacteriosis examination and the presence of a CDI pathogen tests.
Results. The pathogen of C. difficile was isolated in 9.7 % of patients with diarrhea and possible CDI during the examination. Dysbiotic disorders of the intestinal microflora were detected in all patients without exception. The character of microflora abnormalities in both groups corresponded to grade 2 and 3 in severity. The patients with C. difficile showed a reduced number of representatives of normobiocenosis 10 times or more, the prevalence of coccal forms in the total number of microbes and an increase of Candida fungi in the number. It is recommended to include drugs aimed at eliminating the pathogen (metronidazole, fidaxomycin, etc.) or to carry out fecal microbiota transplantation in the schemes of correction of the intestinal microflora in patients with diarrhea in case if C. difficile is detected in their faeces
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