AGE FEATURES OF REMODELING MUSCLES OF TONGUE IN EXPERIMENTAL ANIMALS AT DESQUAMATIVE GLOSSITIS
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i3.10440Keywords:
desquamative glossitis, tongue, muscles, remodelingAbstract
SUMMARY. Desquamative glossitis is an inflammatory and dystrophic lesion of the mucosa of the tongue, which is localized mainly on the back and sides of this organ. Most often this pathology is found in diseases of the gastrointestinal tract and the hematopoetic system. Desquamative glossitis as an independent pathology is often found, and its diagnosis is not easy.
The aim – to study the age-old features of the remodeling of the muscle of the tongue at desquamative glossitis.
Material and Methods. The complex of morphological methods examined the tongue muscles of 60 laboratory mature white male rats, which were divided into 4 groups. The group 1 consisted of 15 8-month-old animals that were under normal vivarium conditions, group 2 – 15 the same 24-month-old rats, group 3 – 15 8-month-old animals with simulated desquamative glossitis, group 4 – 15 24-month-old rats with desquamative glossitis.
The microtomy sections of the tongue were stained with hematoxylin-eosin, for van Gizon, Mallory, and toluidine blue. The diameter of muscle fibers, their nuclei, nuclear-cytoplasmic ratios in these structures, relative volumes of stroma, muscle, stromal-myocyte ratio, relative volume of damaged muscle fibers were Mmorphometrically determined. Histological preparations were also investigated in polarized light. Quantitative indicators were processed statistically.
Results. It was established that desquamative glossitis in laboratory white male rats, in addition to remodeling of the structures of the mucosa, leads to the morphological reorganization of the muscles of the tongue, which is characterized by moderate atrophy, a violation of tissue and cellular structural homeostasis, an increase in the relative volume of damaged muscle fibers, dystrophy, necrobiosis and contracture damage, infiltration and sclerosis. The degree of remodeling of the muscles of the tongue dominated the upper longitudinal muscle and old animal. The latter was confirmed by the relative volumes of damaged muscle fibers, which in young rats was equal (12.40±0.15) %, and in the old – (19.60±0.18) % (p <0.001).
Conclusions. Desquamative glossitis in laboratory white male rats, in addition to remodeling the structures of the mucosa, leads to a morphological alteration of the muscles of the tongue, which is characterized by moderate atrophy, a violation of tissue and cellular structural homeostasis, an increase in the relative volume of damaged muscle fibers, dystrophy, necrobiosis and contractal damage to them. The degree of remodeling of the muscles of the tongue was dominated by the upper longitudinal muscle of the tongue and in the experimental animals of the older age group.
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